Examination of the usefulness of next-generation sequencing in mixed DNA samples

Fumi Momota, Akiko Tsuji, Atsushi Ishiko, Noriaki Ikeda

研究成果: Contribution to journalArticle査読

抄録

The identification of individuals from mixed DNA samples is an important application of DNA typing. Although the discriminatory power of DNA profiling has improved dramatically, a limiting factor is that individuals cannot be identified via short tandem repeat (STR) analysis. We used next-generation sequencing (NGS) to examine the mixed DNA samples. Our results showed that STR nucleotide sequences and single nucleotide polymorphisms (SNPs) analysis via NGS may enable the identification of each distinct subject from a DNA mixture containing DNA of the victim and suspect.

本文言語英語
論文番号101874
ジャーナルLegal Medicine
51
DOI
出版ステータス出版済み - 7 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 諸問題の倫理的、法的側面

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