Excitatory effects of ATP on rat dorsomedial hypothalamic neurons

N. Matsumoto, M. Sorimachi, N. Akaike

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

We investigated P2X purinoceptors in rat dorsomedial hypothalamic (DMH) neurons using nystatin-perforated patch-clamp recordings and fura-2 microfluorometry. Adenosine triphosphate (ATP) concentration-dependently evoked an inward current and increased cytosolic Ca2+ ([Ca]i). The rise in [Ca]i was dependent on external Ca2+ and Na+, was blocked by Ca2+ channel antagonists and had pharmacological properties consistent with P2X2 receptors. These results suggest that P2X receptor-mediated depolarization activates voltage-gated Ca 2+ channels, resulting in an increase in [Ca]i.

本文言語英語
ページ(範囲)234-237
ページ数4
ジャーナルBrain Research
1009
1-2
DOI
出版ステータス出版済み - 5 29 2004

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

フィンガープリント

「Excitatory effects of ATP on rat dorsomedial hypothalamic neurons」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル