Excited state proton transfer dynamics of Topotecan inside biomimicking nanocavity

Raj Kumar Koninti, Krishna Gavvala, Abhigyan Sengupta, Partha Hazra

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

The excited state proton transfer (ESPT) dynamics of a potentially important anticancer drug, Topotecan (TPT), has been explored in aqueous reverse micelle (RM) using steady-state and time-resolved fluorescence measurements. Both the time-resolved emission spectrum and time-resolved area normalized emission spectrum infer the generation of excited state zwitterionic form of TPT from the excited state cationic form of TPT, as a result of ESPT process from the -OH group of TPT to the nearby water molecule. The ESPT dynamics were found to be severely retarded inside the nanocavities of RMs, yielding time constants of 250 ps to 1.0 ns, which is significantly slower than the dynamics obtained in bulk water (32 ps). The observed slow ESPT dynamics in RM compared to bulk water is mainly attributed to the sluggish hydrogen-bonded network dynamics of water molecules inside the nanocavity of RM and the screening of the sodium ions present at the interface.

本文言語英語
ページ(範囲)2363-2371
ページ数9
ジャーナルJournal of Physical Chemistry B
119
6
DOI
出版ステータス出版済み - 2 12 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 物理化学および理論化学
  • 表面、皮膜および薄膜
  • 材料化学

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