Exogenous hypercholesterolemic rats, compared with their progenitor, Sprague-Dawley rats, promptly alter cholesterol metabolism in the liver and secrete cholesterol-rich particles in response to dietary cholesterol

Masanobu Sakono, Haruhiko Mori, Koji Nagao, Masao Sato, Ikuo Ikeda, Kyosuke Yamamoto, Katsumi Imaizumi

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Early responses of cholesterol metabolism to dietary cholesterol were compared between exogenous hypercholesterolemic (ExHC) and Sprague-Dawley rats. Both strains had a similar radioactivity of [14C]cholesterol in the serum half a day after the oral administration, but thereafter the radioactivity disappeared slowly in ExHC rats. ExHC rats promptly altered in response to the dietary cholesterol, activities of cholesterol 7α-hydroxylase and cholesterol synthesis in the liver and fecal excretion of bile acids derived from [14C]cholesterol administered orally. Lymphatic transport for 24 hr of [14C]cholesterol was similar between the strains. Triton administration resulted in a marked accumulation of cholesterol in serum d > 1.006 g/ml lipoproteins in ExHC rats; in addition, the formation of cholesteryl esters from [14C]oleic acid intravenously infused was greater in ExHC rats. These results indicate that ExHC rats increase serum cholesterol in response to enous cholesterol by decreasing the liver uptake and enhancing the secretion in the liver.

本文言語英語
ページ(範囲)803-808
ページ数6
ジャーナルComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
113
4
DOI
出版ステータス出版済み - 1 1 1996

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 分子生物学

フィンガープリント

「Exogenous hypercholesterolemic rats, compared with their progenitor, Sprague-Dawley rats, promptly alter cholesterol metabolism in the liver and secrete cholesterol-rich particles in response to dietary cholesterol」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル