Exploring the Role of Manganese on the Microstructure, Mechanical Properties, Biodegradability, and Biocompatibility of Porous Iron-Based Scaffolds

Matthew S. Dargusch, Ali Dehghan-Manshadi, Mahboobeh Shahbazi, Jeffrey Venezuela, Xuan Tran, Jing Song, Na Liu, Chun Xu, Qinsong Ye, Cuie Wen

研究成果: ジャーナルへの寄稿学術誌査読

42 被引用数 (Scopus)

抄録

In this work, the role that manganese plays in determining the structure and performance of sintered biodegradable porous Fe-Mn alloys is described. Powder metallurgy processing was employed to produce a series of biodegradable porous Fe-xMn (x = 20, 30, and 35 wt %) alloys suitable for bone scaffold applications. Increasing manganese content increased the porosity volume in the sintered alloys and influenced the ensuing properties of the metal. The Fe-35Mn alloy possessed optimum properties for orthopedic application. X-ray diffraction analysis and magnetic characterization confirmed the predominance of the antiferromagnetic austenitic phase and ensured the magnetic resonance imaging (MRI) compatibility of this alloy. The porous Fe-35Mn alloy possessed mechanical properties (tensile strength of 144 MPa, elastic modulus of 53.3 GPa) comparable to human cortical bone. The alloy exhibited high degradation rates (0.306 mm year-1) in simulated physiological fluid, likely due to its considerable Mn content and the high surface area inherent to its porous structures, while cytotoxicity and morphometry tests using mammalian preosteoblast cells (MC3T3-E1) indicated good cell viability in the Fe-35Mn alloy.

本文言語英語
ページ(範囲)1686-1702
ページ数17
ジャーナルACS Biomaterials Science and Engineering
5
4
DOI
出版ステータス出版済み - 4月 8 2019
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生体材料
  • 生体医工学

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