Expression analysis of P/Q-type Ca2+ channel α1A subunit mRNA in olfactory mitral cell in N-type Ca 2+ channel α1B subunit gene-deficient mice

Eiki Takahashi, Mitsuhiro Ino, Norimasa Miyamoto, Takeshi Nagasu

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)


N-type and P/Q-type Ca2+ channels play an important role in the processing of olfactory information. However, N-type Ca2+ channel α1B-deficient mice show normal behavior, presumably owing to compensation by other Ca2+ channels. P/Q-type Ca2+ channel α1A mRNA was expressed at a higher level in olfactory bulb of homozygous α1B-deficient mice than wild-type or heterozygous mice. LacZ expression in olfactory mitral cells of homozygous α1B-deficient x α1A1.5-lacZ mice, carrying a 1.5-kb 5′-upstream fragment of the α1A gene fused to the lacZ reporter gene, was increased compared to that in wild-type or heterozygous mice. Therefore, a possible explanation for the normal behavior of α1B-deficient mice is compensation by the α1A gene and that the 1.5-kb 5′-upstream region of this gene contains an enhancer cis-element for compensation in olfactory mitral cells.

ジャーナルNeuroscience Letters
出版ステータス出版済み - 4 8 2004

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)


「Expression analysis of P/Q-type Ca<sup>2+</sup> channel α<sub>1A</sub> subunit mRNA in olfactory mitral cell in N-type Ca <sup>2+</sup> channel α<sub>1B</sub> subunit gene-deficient mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。