Expression of activated signal transducer and activator Stat3 as a predictor of poor prognosis in cervical cancer

Kenzo Sonoda

研究成果: Contribution to journalComment/debate査読

抄録

Evaluation of: Takemoto S, Ushijima K, Kawano K et al. Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma. Br. J. Cancer 101(6), 967-972 (2009). Stat3 is activated through phosphorylation (p-Stat3), whereupon it enhances the transcription of several molecules involved in cell survival and proliferation. The constitutive activation of Stat3 has been reported in various types of malignancies, and its expression has been shown to indicate a poor prognosis. However, the clinical significance of Stat3 expression in cervical cancer has seldom been evaluated. Using immunohistochemical methods, Takemoto et al. investigated the association between p-Stat3 expression and clinicopathological variables. The expression of p-Stat3 was significantly correlated with stage, tumor size, lymph vascular space invasion and lymph node metastasis. Furthermore, p-Stat3 expression was statistically indicative of a poor prognosis. These data demonstrate the clinical significance of p-Stat3 expression. Continued studies of Stat3 function may help in the development of novel therapeutic strategies for cervical cancer.

本文言語英語
ページ(範囲)161-164
ページ数4
ジャーナルExpert Review of Obstetrics and Gynecology
5
2
DOI
出版ステータス出版済み - 3 2010

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Maternity and Midwifery

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