Expression of activation-induced cytidine deaminase in ulcerative colitis-associated carcinogenesis

Masaki Gushima, Minako Hirahashi, Takayuki Matsumoto, Kouhei Fujita, Kenoki Ohuchida, Yoshinao Oda, Takashi Yao, Mitsuo Iida, Masazumi Tsuneyoshi

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Aims: Activation-induced cytidine deaminase (AID) is a DNA/RNA-editing enzyme that is essential for hypermutation and class-switch recombination in immunoglobulin genes. The aim of this study was to investigate the expression of AID and its association with p53 mutation in ulcerative colitis (UC)-associated carcinogenesis. Methods and results: The expression of AID was examined in 25 patients with UC-associated neoplasia, 20 UC patients without neoplasia, 18 patients with non-inflamed colorectal mucosa unaffected by UC, and 19 patients with sporadic colorectal cancer, by immunohistochemistry and quantitative reverse transcription polymerase chain reaction analysis. Mutational analysis and immunohistochemistry for p53 were also performed. The degree of AID expression was not different between UC-associated neoplasia and sporadic colorectal cancer. However, AID was expressed in both UC-associated neoplasia and UC without neoplasia. Whereas AID expression in UC-associated neoplasia was not correlated with the grade of dysplasia, expression in non-neoplastic mucosa of UC was correlated with the histological grade of inflammation. In UC-associated neoplasia, there was no significant correlation between AID expression and p53 mutation. Conclusions: AID is associated with inflammation in UC, whereas it may not specifically contribute to carcinogenesis in UC.

本文言語英語
ページ(範囲)460-469
ページ数10
ジャーナルHistopathology
59
3
DOI
出版ステータス出版済み - 9 2011

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 組織学

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