抄録
Summary Medullary carcinoma (MC) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 poorly differentiated adenocarcinomas (PDAs). The expressions of membranous E-cadherin (P <.0001), β-catenin (P <.0001) and claudin 1 (P =.0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the PDAs. E-cadherin membranous expression was also significantly preserved in the central portion of the MCs (P =.0178). Nuclear β-catenin expression in both the central portion (P =.0463) and invasive front (P =.0346) of the MCs was significantly less frequent compared to that in the PDAs. Snail (P =.0035) and Twist1 (P =.0463) expressions in the invasive front of the MCs were significantly less frequent compared to the PDAs, suggesting that the EMT phenomenon may occur rarely in colorectal MC. Reduced membranous E-cadherin expression in the MC central portion was significantly correlated with poor clinical outcome (P =.0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of E-cadherin in the central portion might be a good biomarker for an unfavorable prognosis in cases of MC.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1257-1266 |
| ページ数 | 10 |
| ジャーナル | Human Pathology |
| 巻 | 46 |
| 発行部数 | 9 |
| DOI | |
| 出版物ステータス | 出版済み - 9 1 2015 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
これを引用
Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. / Takahashi, Shunsuke; Kohashi, Kenichi; Yamamoto, Hidetaka; Hirahashi, Minako; Kumagai, Reiko; Takizawa, Nobuyoshi; Nakamura, Kazuhiko; Maehara, Yoshihiko; Tanaka, Masao; Takayanagi, Ryoichi; Oda, Yoshinao.
：: Human Pathology, 巻 46, 番号 9, 01.09.2015, p. 1257-1266.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum
AU - Takahashi, Shunsuke
AU - Kohashi, Kenichi
AU - Yamamoto, Hidetaka
AU - Hirahashi, Minako
AU - Kumagai, Reiko
AU - Takizawa, Nobuyoshi
AU - Nakamura, Kazuhiko
AU - Maehara, Yoshihiko
AU - Tanaka, Masao
AU - Takayanagi, Ryoichi
AU - Oda, Yoshinao
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Summary Medullary carcinoma (MC) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 poorly differentiated adenocarcinomas (PDAs). The expressions of membranous E-cadherin (P <.0001), β-catenin (P <.0001) and claudin 1 (P =.0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the PDAs. E-cadherin membranous expression was also significantly preserved in the central portion of the MCs (P =.0178). Nuclear β-catenin expression in both the central portion (P =.0463) and invasive front (P =.0346) of the MCs was significantly less frequent compared to that in the PDAs. Snail (P =.0035) and Twist1 (P =.0463) expressions in the invasive front of the MCs were significantly less frequent compared to the PDAs, suggesting that the EMT phenomenon may occur rarely in colorectal MC. Reduced membranous E-cadherin expression in the MC central portion was significantly correlated with poor clinical outcome (P =.0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of E-cadherin in the central portion might be a good biomarker for an unfavorable prognosis in cases of MC.
AB - Summary Medullary carcinoma (MC) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 poorly differentiated adenocarcinomas (PDAs). The expressions of membranous E-cadherin (P <.0001), β-catenin (P <.0001) and claudin 1 (P =.0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the PDAs. E-cadherin membranous expression was also significantly preserved in the central portion of the MCs (P =.0178). Nuclear β-catenin expression in both the central portion (P =.0463) and invasive front (P =.0346) of the MCs was significantly less frequent compared to that in the PDAs. Snail (P =.0035) and Twist1 (P =.0463) expressions in the invasive front of the MCs were significantly less frequent compared to the PDAs, suggesting that the EMT phenomenon may occur rarely in colorectal MC. Reduced membranous E-cadherin expression in the MC central portion was significantly correlated with poor clinical outcome (P =.0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of E-cadherin in the central portion might be a good biomarker for an unfavorable prognosis in cases of MC.
UR - http://www.scopus.com/inward/record.url?scp=84940459310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940459310&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2015.05.023
DO - 10.1016/j.humpath.2015.05.023
M3 - Article
C2 - 26208847
AN - SCOPUS:84940459310
VL - 46
SP - 1257
EP - 1266
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 9
ER -