Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum

Shunsuke Takahashi, Kenichi Kouhashi, Hidetaka Yamamoto, Minako Hirahashi, Reiko Kumagai, Nobuyoshi Takizawa, Kazuhiko Nakamura, Yoshihiko Maehara, Masao Tanaka, Ryoichi Takayanagi, Yoshinao Oda

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Summary Medullary carcinoma (MC) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 poorly differentiated adenocarcinomas (PDAs). The expressions of membranous E-cadherin (P <.0001), β-catenin (P <.0001) and claudin 1 (P =.0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the PDAs. E-cadherin membranous expression was also significantly preserved in the central portion of the MCs (P =.0178). Nuclear β-catenin expression in both the central portion (P =.0463) and invasive front (P =.0346) of the MCs was significantly less frequent compared to that in the PDAs. Snail (P =.0035) and Twist1 (P =.0463) expressions in the invasive front of the MCs were significantly less frequent compared to the PDAs, suggesting that the EMT phenomenon may occur rarely in colorectal MC. Reduced membranous E-cadherin expression in the MC central portion was significantly correlated with poor clinical outcome (P =.0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of E-cadherin in the central portion might be a good biomarker for an unfavorable prognosis in cases of MC.

元の言語英語
ページ(範囲)1257-1266
ページ数10
ジャーナルHuman Pathology
46
発行部数9
DOI
出版物ステータス出版済み - 9 1 2015

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Medullary Carcinoma
Epithelial-Mesenchymal Transition
Cadherins
Adenocarcinoma
Catenins
Claudin-1
Colorectal Neoplasms
Proteins
Transcription Factors
Biomarkers

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

これを引用

Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. / Takahashi, Shunsuke; Kouhashi, Kenichi; Yamamoto, Hidetaka; Hirahashi, Minako; Kumagai, Reiko; Takizawa, Nobuyoshi; Nakamura, Kazuhiko; Maehara, Yoshihiko; Tanaka, Masao; Takayanagi, Ryoichi; Oda, Yoshinao.

:: Human Pathology, 巻 46, 番号 9, 01.09.2015, p. 1257-1266.

研究成果: ジャーナルへの寄稿記事

Takahashi, S, Kouhashi, K, Yamamoto, H, Hirahashi, M, Kumagai, R, Takizawa, N, Nakamura, K, Maehara, Y, Tanaka, M, Takayanagi, R & Oda, Y 2015, 'Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum', Human Pathology, 巻. 46, 番号 9, pp. 1257-1266. https://doi.org/10.1016/j.humpath.2015.05.023
Takahashi, Shunsuke ; Kouhashi, Kenichi ; Yamamoto, Hidetaka ; Hirahashi, Minako ; Kumagai, Reiko ; Takizawa, Nobuyoshi ; Nakamura, Kazuhiko ; Maehara, Yoshihiko ; Tanaka, Masao ; Takayanagi, Ryoichi ; Oda, Yoshinao. / Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. :: Human Pathology. 2015 ; 巻 46, 番号 9. pp. 1257-1266.
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abstract = "Summary Medullary carcinoma (MC) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 poorly differentiated adenocarcinomas (PDAs). The expressions of membranous E-cadherin (P <.0001), β-catenin (P <.0001) and claudin 1 (P =.0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the PDAs. E-cadherin membranous expression was also significantly preserved in the central portion of the MCs (P =.0178). Nuclear β-catenin expression in both the central portion (P =.0463) and invasive front (P =.0346) of the MCs was significantly less frequent compared to that in the PDAs. Snail (P =.0035) and Twist1 (P =.0463) expressions in the invasive front of the MCs were significantly less frequent compared to the PDAs, suggesting that the EMT phenomenon may occur rarely in colorectal MC. Reduced membranous E-cadherin expression in the MC central portion was significantly correlated with poor clinical outcome (P =.0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of E-cadherin in the central portion might be a good biomarker for an unfavorable prognosis in cases of MC.",
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AU - Takahashi, Shunsuke

AU - Kouhashi, Kenichi

AU - Yamamoto, Hidetaka

AU - Hirahashi, Minako

AU - Kumagai, Reiko

AU - Takizawa, Nobuyoshi

AU - Nakamura, Kazuhiko

AU - Maehara, Yoshihiko

AU - Tanaka, Masao

AU - Takayanagi, Ryoichi

AU - Oda, Yoshinao

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AB - Summary Medullary carcinoma (MC) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 poorly differentiated adenocarcinomas (PDAs). The expressions of membranous E-cadherin (P <.0001), β-catenin (P <.0001) and claudin 1 (P =.0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the PDAs. E-cadherin membranous expression was also significantly preserved in the central portion of the MCs (P =.0178). Nuclear β-catenin expression in both the central portion (P =.0463) and invasive front (P =.0346) of the MCs was significantly less frequent compared to that in the PDAs. Snail (P =.0035) and Twist1 (P =.0463) expressions in the invasive front of the MCs were significantly less frequent compared to the PDAs, suggesting that the EMT phenomenon may occur rarely in colorectal MC. Reduced membranous E-cadherin expression in the MC central portion was significantly correlated with poor clinical outcome (P =.0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of E-cadherin in the central portion might be a good biomarker for an unfavorable prognosis in cases of MC.

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