Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells

Akiko Joo Okumura, Luke F. Peterson, Miao Chia Lo, Dong Er Zhang

研究成果: ジャーナルへの寄稿学術誌査読

26 被引用数 (Scopus)

抄録

Runx1/AML1 plays important roles in hematopoiesis, including the commitment of cells to hematopoiesis during embryonic development, and in the maintenance of hematopoietic cell populations. It is also one of the most common genes involved in chromosomal translocations related to leukemia. One such translocation is t(8;21), which fuses the Runx1 gene to the MTG8/ETO gene and generates the Runx1-MTG8 (AML1-ETO) fusion gene. Both Runx1 and MTG8 have two additional family members that are much less studied in hematopoiesis. Here we report the expression of every member of the Runx and MTG families as well as the Runx heterodimerization partner CBFβ during hematopoietic differentiation of murine embryonic stem cells. We observed substantially increased expression of Runx1, Runx2, and MTG16 during hematopoietic differentiation. Furthermore, the increase in Runx2 expression is delayed relative to Runx1 expression, suggesting their possible sequential contribution to hematopoiesis.

本文言語英語
ページ(範囲)978-988
ページ数11
ジャーナルExperimental Hematology
35
6
DOI
出版ステータス出版済み - 6月 2007
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 血液学
  • 遺伝学
  • 細胞生物学
  • 癌研究

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