Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection

Takaaki Fujimoto, Ohtsuka Takao, Kenjiro Date, Hideyo Kimura, Taketo Matsunaga, Yasuhisa Mori, Yoshihiro Miyasaka, Naoki Mochidome, Yoshinao Oda, Masafumi Nakamura

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Background: An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. Methods: The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. Results: The 5-year overall survival rate in the study population was 62%. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. Conclusions: BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.

元の言語英語
ページ(範囲)489-496
ページ数8
ジャーナルJournal of Hepato-Biliary-Pancreatic Sciences
23
発行部数8
DOI
出版物ステータス出版済み - 8 1 2016

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Carcinoma
Thymidylate Synthase
Proteins
Adjuvant Chemotherapy
gemcitabine
Patient Selection
Multivariate Analysis
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Recurrence
Survival
Pharmaceutical Preparations
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology

これを引用

Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection. / Fujimoto, Takaaki; Takao, Ohtsuka; Date, Kenjiro; Kimura, Hideyo; Matsunaga, Taketo; Mori, Yasuhisa; Miyasaka, Yoshihiro; Mochidome, Naoki; Oda, Yoshinao; Nakamura, Masafumi.

:: Journal of Hepato-Biliary-Pancreatic Sciences, 巻 23, 番号 8, 01.08.2016, p. 489-496.

研究成果: ジャーナルへの寄稿記事

Fujimoto, Takaaki ; Takao, Ohtsuka ; Date, Kenjiro ; Kimura, Hideyo ; Matsunaga, Taketo ; Mori, Yasuhisa ; Miyasaka, Yoshihiro ; Mochidome, Naoki ; Oda, Yoshinao ; Nakamura, Masafumi. / Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection. :: Journal of Hepato-Biliary-Pancreatic Sciences. 2016 ; 巻 23, 番号 8. pp. 489-496.
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abstract = "Background: An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. Methods: The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. Results: The 5-year overall survival rate in the study population was 62{\%}. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. Conclusions: BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.",
author = "Takaaki Fujimoto and Ohtsuka Takao and Kenjiro Date and Hideyo Kimura and Taketo Matsunaga and Yasuhisa Mori and Yoshihiro Miyasaka and Naoki Mochidome and Yoshinao Oda and Masafumi Nakamura",
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AU - Fujimoto, Takaaki

AU - Takao, Ohtsuka

AU - Date, Kenjiro

AU - Kimura, Hideyo

AU - Matsunaga, Taketo

AU - Mori, Yasuhisa

AU - Miyasaka, Yoshihiro

AU - Mochidome, Naoki

AU - Oda, Yoshinao

AU - Nakamura, Masafumi

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N2 - Background: An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. Methods: The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. Results: The 5-year overall survival rate in the study population was 62%. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. Conclusions: BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.

AB - Background: An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. Methods: The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. Results: The 5-year overall survival rate in the study population was 62%. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. Conclusions: BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.

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