Expression of brain natriuretic peptide gene in human heart: Production in the ventricle

Kiminori Hosoda, Kazuwa Nakao, Masashi Mukoyama, Yoshihiko Saito, Michihisa Jougasaki, Gotaro Shirakami, Shin Ichi Suga, Yoshihiro Ogawa, Hirofumi Yasue, Hiroo Imura

研究成果: ジャーナルへの寄稿記事

228 引用 (Scopus)

抄録

To elucidate the expression of the brain natriuretic peptide gene in the human heart, we have measured brain natriuretic peptide mRNA levels in hearts using the Northern blot hybridization method. Brain natriuretic peptide mRNA was present with a size of approximately 0.9 kb in the ventricle as well as in the atrium. The brain natriuretic peptide mRNA level in the ventricle was 52% of that in the atrium, whereas the atrial natriuretic peptide mRNA level in the ventricle was approximately two orders of magnitude lower than that in the atrium. Taking atrial and ventricular weights into account, the total amount of brain natriuretic peptide mRNA in the ventricle represented 77% of that in the whole heart. These results demonstrate that most of brain natriuretic peptide mRNA occurs in the ventricle, in contrast with atrial natriuretic peptide mRNA, which is present mainly in the atrium, indicating that the ventricle is a major production site of brain natriuretic peptide.

元の言語英語
ページ(範囲)1152-1156
ページ数5
ジャーナルHypertension
17
発行部数6 SUPPL. 2
出版物ステータス出版済み - 6 1991
外部発表Yes

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Brain Natriuretic Peptide
Messenger RNA
Genes
Atrial Natriuretic Factor
Northern Blotting
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Hosoda, K., Nakao, K., Mukoyama, M., Saito, Y., Jougasaki, M., Shirakami, G., ... Imura, H. (1991). Expression of brain natriuretic peptide gene in human heart: Production in the ventricle. Hypertension, 17(6 SUPPL. 2), 1152-1156.

Expression of brain natriuretic peptide gene in human heart : Production in the ventricle. / Hosoda, Kiminori; Nakao, Kazuwa; Mukoyama, Masashi; Saito, Yoshihiko; Jougasaki, Michihisa; Shirakami, Gotaro; Suga, Shin Ichi; Ogawa, Yoshihiro; Yasue, Hirofumi; Imura, Hiroo.

:: Hypertension, 巻 17, 番号 6 SUPPL. 2, 06.1991, p. 1152-1156.

研究成果: ジャーナルへの寄稿記事

Hosoda, K, Nakao, K, Mukoyama, M, Saito, Y, Jougasaki, M, Shirakami, G, Suga, SI, Ogawa, Y, Yasue, H & Imura, H 1991, 'Expression of brain natriuretic peptide gene in human heart: Production in the ventricle', Hypertension, 巻. 17, 番号 6 SUPPL. 2, pp. 1152-1156.
Hosoda K, Nakao K, Mukoyama M, Saito Y, Jougasaki M, Shirakami G その他. Expression of brain natriuretic peptide gene in human heart: Production in the ventricle. Hypertension. 1991 6;17(6 SUPPL. 2):1152-1156.
Hosoda, Kiminori ; Nakao, Kazuwa ; Mukoyama, Masashi ; Saito, Yoshihiko ; Jougasaki, Michihisa ; Shirakami, Gotaro ; Suga, Shin Ichi ; Ogawa, Yoshihiro ; Yasue, Hirofumi ; Imura, Hiroo. / Expression of brain natriuretic peptide gene in human heart : Production in the ventricle. :: Hypertension. 1991 ; 巻 17, 番号 6 SUPPL. 2. pp. 1152-1156.
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abstract = "To elucidate the expression of the brain natriuretic peptide gene in the human heart, we have measured brain natriuretic peptide mRNA levels in hearts using the Northern blot hybridization method. Brain natriuretic peptide mRNA was present with a size of approximately 0.9 kb in the ventricle as well as in the atrium. The brain natriuretic peptide mRNA level in the ventricle was 52{\%} of that in the atrium, whereas the atrial natriuretic peptide mRNA level in the ventricle was approximately two orders of magnitude lower than that in the atrium. Taking atrial and ventricular weights into account, the total amount of brain natriuretic peptide mRNA in the ventricle represented 77{\%} of that in the whole heart. These results demonstrate that most of brain natriuretic peptide mRNA occurs in the ventricle, in contrast with atrial natriuretic peptide mRNA, which is present mainly in the atrium, indicating that the ventricle is a major production site of brain natriuretic peptide.",
author = "Kiminori Hosoda and Kazuwa Nakao and Masashi Mukoyama and Yoshihiko Saito and Michihisa Jougasaki and Gotaro Shirakami and Suga, {Shin Ichi} and Yoshihiro Ogawa and Hirofumi Yasue and Hiroo Imura",
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AU - Jougasaki, Michihisa

AU - Shirakami, Gotaro

AU - Suga, Shin Ichi

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