Expression of brain natriuretic peptide gene in human heart: Production in the ventricle

Kiminori Hosoda, Kazuwa Nakao, Masashi Mukoyama, Yoshihiko Saito, Michihisa Jougasaki, Gotaro Shirakami, Shin Ichi Suga, Yoshihiro Ogawa, Hirofumi Yasue, Hiroo Imura

研究成果: Contribution to journalArticle査読

229 被引用数 (Scopus)

抄録

To elucidate the expression of the brain natriuretic peptide gene in the human heart, we have measured brain natriuretic peptide mRNA levels in hearts using the Northern blot hybridization method. Brain natriuretic peptide mRNA was present with a size of approximately 0.9 kb in the ventricle as well as in the atrium. The brain natriuretic peptide mRNA level in the ventricle was 52% of that in the atrium, whereas the atrial natriuretic peptide mRNA level in the ventricle was approximately two orders of magnitude lower than that in the atrium. Taking atrial and ventricular weights into account, the total amount of brain natriuretic peptide mRNA in the ventricle represented 77% of that in the whole heart. These results demonstrate that most of brain natriuretic peptide mRNA occurs in the ventricle, in contrast with atrial natriuretic peptide mRNA, which is present mainly in the atrium, indicating that the ventricle is a major production site of brain natriuretic peptide.

本文言語英語
ページ(範囲)1152-1156
ページ数5
ジャーナルHypertension
17
6 SUPPL. 2
DOI
出版ステータス出版済み - 6 1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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