Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus

Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Taito Matsuda, Masakazu Namihira, Kinichi Nakashima

研究成果: Contribution to journalArticle査読

23 被引用数 (Scopus)

抄録

Adult neurogenesis persists throughout life in the dentate gyrus (DG) of the hippocampus, and its importance has been highlighted in hippocampus-dependent learning and memory. Adult neurogenesis consists of multiple processes: maintenance and neuronal differentiation of neural stem/precursor cells (NS/PCs), followed by survival and maturation of newborn neurons and their integration into existing neuronal circuitry. However, the mechanisms that govern these processes remain largely unclear. Here we show that DNA methyltransferase 1 (DNMT1), an enzyme responsible for the maintenance of DNA methylation, is highly expressed in proliferative cells in the adult DG and plays an important role in the survival of newly generated neurons. Deletion of Dnmt1 in adult NS/PCs (aNS/PCs) did not affect the proliferation and differentiation of aNS/PCs per se. However, it resulted in a decrease of newly generated mature neurons, probably due to gradual cell death after aNS/PCs differentiated into neurons in the hippocampus. Interestingly, loss of DNMT1 in post-mitotic neurons did not influence their survival. Taken together, these findings suggest that the presence of DNMT1 in aNS/PCs is crucial for the survival of newly generated neurons, but is dispensable once they accomplish neuronal differentiation in the adult hippocampus.

本文言語英語
ページ(範囲)1-11
ページ数11
ジャーナルNeuroscience Research
95
DOI
出版ステータス出版済み - 6 1 2015

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

フィンガープリント

「Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル