Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles

Hiroko Iwamasa, Kunimasa Ohta, Tomoko Yamada, Kazuo Ushijima, Hidenori Terasaki, Hideaki Tanaka

研究成果: Contribution to journalArticle査読

55 被引用数 (Scopus)

抄録

Evidence is accumulating that Eph receptor tyrosine kinases and their ligands regulate cell migration and axonal guidance during development. It was previously found that one of the Eph receptors, EphA4, is transiently expressed in subsets of chick embryonic motor neurons. Here, the expression of EphA and ephrin- A subfamily members was further examined, and the dynamic patterns of expression in chick embryonic motor neurons found. EphA3, EphA4, ephrin-A2, and ephrin-A5 were also expressed in the connective tissues of limb muscles and EphA3 and EphA4 expressing motor neurons innervated EphA3 and EphA4 expressing limb muscles, respectively. These spatiotemporal expression patterns suggest that EphA and ephrin-A proteins play important roles in muscle patterning and motor axonal guidance.

本文言語英語
ページ(範囲)685-698
ページ数14
ジャーナルDevelopment Growth and Differentiation
41
6
DOI
出版ステータス出版済み - 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 発生生物学
  • 細胞生物学

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