Expression of erythroid‐specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome

ETSURO ITO, MIKIO KASAI, YASOHIDE HAYASHI, TSUTOMU TOKI, KOJI ARAI, SHINKICHI YOKOYAMA, KOJI KATO, NAOKI TACHIBANA, MASAYUKI YAMAMOTO, MASARU YOKOYAMA

研究成果: Contribution to journalArticle査読

46 被引用数 (Scopus)

抄録

Summary. Acute megakaryoblastic leukaemia (M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers. To clarify properties of the blast cells in M7 and TMD cases, we examined erythroid markers expression in blasts from six cases with M7 and seven cases with TMD in this study. Erythroid‐specific mRNAs encoding 7‐globin and erythroid 6‐aminolevulinate synthase were found to be expressed in blasts from most of these cases, indicating that majorities of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes. We also found that mRNAs encoding GATA‐1 and GATA‐2 are expressed in all these cases. These results suggest that M7 blasts and TMD blasts correspond to the erythroid/megakaryocytic bipotential progenitor cells.

本文言語英語
ページ(範囲)607-614
ページ数8
ジャーナルBritish Journal of Haematology
90
3
DOI
出版ステータス出版済み - 7 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • Hematology

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