Expression of granulysin in polymyositis and inclusion-body myositis

K. Ikezoe, S. Ohshima, M. Osoegawa, M. Tanaka, K. Ogawa, K. Nagata, J. I. Kira

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

Background: Granulysin, a recently defined cytolytic molecule, is expressed in cytotoxic T cells and natural killer cells in a similar way to perforin, which is reported to have a major role in the pathogenesis of polymyositis and inclusion-body myositis (IBM). Objective: To clarify the role of granulysin in polymyositis and IBM. Methods: The expression of granulysin and perform was examined by double staining with CD8, CD4 and CD56 in endomysial infiltrating cells and autoinvasive cells in muscle biopsy specimens of 17 patients with polymyositis (6 steroid resistant and 11 steroid responsive) and of 7 patients with IBM. Results: Similar to perform, granulysin was expressed in CD8, CD4 or CD56 cells in patients with polymyositis and IBM. The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Conclusion: Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis.

本文言語英語
ページ(範囲)1187-1190
ページ数4
ジャーナルJournal of Neurology, Neurosurgery and Psychiatry
77
10
DOI
出版ステータス出版済み - 10 2006

All Science Journal Classification (ASJC) codes

  • 外科
  • 臨床神経学
  • 精神医学および精神衛生

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