Expression of hepatocyte growth factor gene in endothelial and kupffer cells of damaged rat livers, as revealed by in situ hydridization

Sumihara Noji, Kosuke Tashiro, Eiki Koyama, Tsutomu Nohno, Kazuhiko Ohyama, Shigehiko Taniguchi, Toshikazu Nakamura

研究成果: Contribution to journalArticle査読

275 被引用数 (Scopus)

抄録

Hepatocyte growth factor (HGP) has been demonstrated to be synthesized and secreted by non-parenchymal liver cells for liver regeneration after hepatic injury. We performed in situ hybridization to identify HGF-producing cell types in rat liver hepatitis induced by administrating carbon tetrachloride as a hepatotoxin. We found that transcripts of the HGF gene are localized in the Kupffer and endothelial cells in normal livers and increased remarkably in the Kupffer cells of the damaged livers. Thus, HGF is concluded to be synthesized in the Kupffer and endothelial cells to repair the liver tissue in paracrine fashion. No significant increase in the transcripts of the HGF gene was observed in livers after partial hepatectomy, indicating that a mehcanism on liver regeneration after the hepatectomy differs from that on liver repairs. Since the HGF gene expression was also found in lung and kidney, HGF may be a ubiquitous factor for tissue repairs.

本文言語英語
ページ(範囲)42-47
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
173
1
DOI
出版ステータス出版済み - 11 30 1990

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Expression of hepatocyte growth factor gene in endothelial and kupffer cells of damaged rat livers, as revealed by in situ hydridization」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル