Expression of hepatocyte growth factor gene in endothelial and kupffer cells of damaged rat livers, as revealed by in situ hydridization

Sumihara Noji, Kosuke Tashiro, Eiki Koyama, Tsutomu Nohno, Kazuhiko Ohyama, Shigehiko Taniguchi, Toshikazu Nakamura

研究成果: ジャーナルへの寄稿記事

272 引用 (Scopus)

抄録

Hepatocyte growth factor (HGP) has been demonstrated to be synthesized and secreted by non-parenchymal liver cells for liver regeneration after hepatic injury. We performed in situ hybridization to identify HGF-producing cell types in rat liver hepatitis induced by administrating carbon tetrachloride as a hepatotoxin. We found that transcripts of the HGF gene are localized in the Kupffer and endothelial cells in normal livers and increased remarkably in the Kupffer cells of the damaged livers. Thus, HGF is concluded to be synthesized in the Kupffer and endothelial cells to repair the liver tissue in paracrine fashion. No significant increase in the transcripts of the HGF gene was observed in livers after partial hepatectomy, indicating that a mehcanism on liver regeneration after the hepatectomy differs from that on liver repairs. Since the HGF gene expression was also found in lung and kidney, HGF may be a ubiquitous factor for tissue repairs.

元の言語英語
ページ(範囲)42-47
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
173
発行部数1
DOI
出版物ステータス出版済み - 11 30 1990

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Kupffer Cells
Hepatocyte Growth Factor
Endothelial cells
Liver
Rats
Endothelial Cells
Genes
Liver Regeneration
Hepatectomy
Repair
Carbon Tetrachloride
Thromboplastin
Hepatitis
In Situ Hybridization
Gene expression
Kidney
Gene Expression
Lung
Tissue
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Expression of hepatocyte growth factor gene in endothelial and kupffer cells of damaged rat livers, as revealed by in situ hydridization. / Noji, Sumihara; Tashiro, Kosuke; Koyama, Eiki; Nohno, Tsutomu; Ohyama, Kazuhiko; Taniguchi, Shigehiko; Nakamura, Toshikazu.

:: Biochemical and Biophysical Research Communications, 巻 173, 番号 1, 30.11.1990, p. 42-47.

研究成果: ジャーナルへの寄稿記事

Noji, Sumihara ; Tashiro, Kosuke ; Koyama, Eiki ; Nohno, Tsutomu ; Ohyama, Kazuhiko ; Taniguchi, Shigehiko ; Nakamura, Toshikazu. / Expression of hepatocyte growth factor gene in endothelial and kupffer cells of damaged rat livers, as revealed by in situ hydridization. :: Biochemical and Biophysical Research Communications. 1990 ; 巻 173, 番号 1. pp. 42-47.
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abstract = "Hepatocyte growth factor (HGP) has been demonstrated to be synthesized and secreted by non-parenchymal liver cells for liver regeneration after hepatic injury. We performed in situ hybridization to identify HGF-producing cell types in rat liver hepatitis induced by administrating carbon tetrachloride as a hepatotoxin. We found that transcripts of the HGF gene are localized in the Kupffer and endothelial cells in normal livers and increased remarkably in the Kupffer cells of the damaged livers. Thus, HGF is concluded to be synthesized in the Kupffer and endothelial cells to repair the liver tissue in paracrine fashion. No significant increase in the transcripts of the HGF gene was observed in livers after partial hepatectomy, indicating that a mehcanism on liver regeneration after the hepatectomy differs from that on liver repairs. Since the HGF gene expression was also found in lung and kidney, HGF may be a ubiquitous factor for tissue repairs.",
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AU - Tashiro, Kosuke

AU - Koyama, Eiki

AU - Nohno, Tsutomu

AU - Ohyama, Kazuhiko

AU - Taniguchi, Shigehiko

AU - Nakamura, Toshikazu

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N2 - Hepatocyte growth factor (HGP) has been demonstrated to be synthesized and secreted by non-parenchymal liver cells for liver regeneration after hepatic injury. We performed in situ hybridization to identify HGF-producing cell types in rat liver hepatitis induced by administrating carbon tetrachloride as a hepatotoxin. We found that transcripts of the HGF gene are localized in the Kupffer and endothelial cells in normal livers and increased remarkably in the Kupffer cells of the damaged livers. Thus, HGF is concluded to be synthesized in the Kupffer and endothelial cells to repair the liver tissue in paracrine fashion. No significant increase in the transcripts of the HGF gene was observed in livers after partial hepatectomy, indicating that a mehcanism on liver regeneration after the hepatectomy differs from that on liver repairs. Since the HGF gene expression was also found in lung and kidney, HGF may be a ubiquitous factor for tissue repairs.

AB - Hepatocyte growth factor (HGP) has been demonstrated to be synthesized and secreted by non-parenchymal liver cells for liver regeneration after hepatic injury. We performed in situ hybridization to identify HGF-producing cell types in rat liver hepatitis induced by administrating carbon tetrachloride as a hepatotoxin. We found that transcripts of the HGF gene are localized in the Kupffer and endothelial cells in normal livers and increased remarkably in the Kupffer cells of the damaged livers. Thus, HGF is concluded to be synthesized in the Kupffer and endothelial cells to repair the liver tissue in paracrine fashion. No significant increase in the transcripts of the HGF gene was observed in livers after partial hepatectomy, indicating that a mehcanism on liver regeneration after the hepatectomy differs from that on liver repairs. Since the HGF gene expression was also found in lung and kidney, HGF may be a ubiquitous factor for tissue repairs.

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