Expression of IKKα mRNA in the suprachiasmatic nucleus and circadian rhythms of mice lacking IKKα

Noriko Hayashi, Shinobu Yasuo, Shizufumi Ebihara, Takashi Yoshimura

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

In our previous study, quantitative trait locus (QTL) analysis using mice with abnormal circadian rhythm detected a suggestive QTL, which affects the length of free-running period, on the distal region of Chromosome 19. Among the candidate genes, we have focused on Ikkα gene and found that Ikkα mRNA is expressed in the mammalian circadian pacemaker, the suprachiasmatic nucleus (SCN) in the present study. Expression of Ikkα mRNA in the SCN indicated the possibility that IKKα is involved in the regulation of circadian clock. Therefore, to examine the role of IKKα in the regulation of circadian rhythms, we have further examined wheel-running activity rhythms under light-dark cycle and constant darkness, and circadian response to light. However, we could not detect any statistically significant difference between IKKα+/- mice and wild type mice. Roles of IKKα in the regulation of circadian system remains to be clarified in the future study.

本文言語英語
ページ(範囲)217-221
ページ数5
ジャーナルBrain Research
993
1-2
DOI
出版ステータス出版済み - 12 12 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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