Expression of Integrin alpha-3 and beta-4 subunits on the process of peri-implant epithelium formation

Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Ryosuke Kondo, Kiyoshi Koyano

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Integrin, a component of the hemidesmosome, plays a role for epithelial cell migration and adhesion. This study investigated the process of peri-implant epithelium (PIE) formation after implantation, and compared it to the process of oral mucosa healing after tooth extraction. At the healing site of extraction socket without implant, the original junctional epithelium (JE) had disappeared at week 2, and the oral epithelium (OE) with integrin-α3 positive basal cells extending from the sides of the wound, then joined in the middle of the extraction socket. On the other hand in implant group, newly formed epithelium with integrin-α3 positive cells from the OE extended apically 1 week after implantation. After 3 weeks, basal cells of the new epithelium consisted of those with integrin-α3 positive but β4 negative. Finally, after 4 weeks, integrin-β4 was expressed at the implant-PIE interface. These findings suggest that integrin α3β1 plays a role in cell migration during PIE formation from OE. Furthermore, after the completion of PIE constitution, integrin α6β4 contributes to the attachment to titanium.

本文言語英語
ホスト出版物のタイトルBioceramics 24
出版社Trans Tech Publications Ltd
ページ407-412
ページ数6
1
ISBN(印刷版)9783037855171
DOI
出版ステータス出版済み - 2013
イベント24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, 日本
継続期間: 10 21 201210 24 2012

出版物シリーズ

名前Key Engineering Materials
番号1
529-530
ISSN(印刷版)1013-9826
ISSN(電子版)1662-9795

その他

その他24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
国/地域日本
CityFukuoka
Period10/21/1210/24/12

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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