Expression of integrins in squamous cell carcinoma of the oral cavity: Correlations with tumor invasion and metastasis

Masanori Shinohara, Seiji Nakamura, Masanori Sasaki, Shinichi Kurahara, Tetsuro Ikebe, Takeshi Harada, Kanemitsu Shirasuna

研究成果: Contribution to journalArticle査読

35 被引用数 (Scopus)

抄録

Integrins are cell adhesion molecules that mediate the cell to extracellular matrix interactions. We sought to determine whether the integrin expression on tumor cells is associated with invasive and metastatic potential. First, in 8 cell lines of oral squamous cell carcinoma, 4 of which were metastatic in nude mice and 4 of which were not, integrin expression was examined. When these cell lines were cultured in vitro or transplanted into the tongues of nude mice, the metastatic cell lines tended to show a stronger expression of α2, α3, α5, and α6 integrins than did the nonmetastatic cell lines. Second, integrin expression was immunohistochemically examined in 65 biopsy specimens of primary oral squamous cell carcinoma. In invasive or metastatic cases, a marked expression of α2, α3, α5, and α6 integrins was frequently observed. The association of integrin expression with the mode of tumor invasion and nodal involvement was found to be statistically significant. These results suggest that integrin expression is closely associated with tumor invasion and nodal involvement in oral squamous cell carcinoma.

本文言語英語
ページ(範囲)75-88
ページ数14
ジャーナルAmerican Journal of Clinical Pathology
111
1
DOI
出版ステータス出版済み - 1999

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

フィンガープリント

「Expression of integrins in squamous cell carcinoma of the oral cavity: Correlations with tumor invasion and metastasis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル