Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement

Aiko Suminoe, Akinobu Matsuzaki, Hiroyoshi Hattori, Yuhki Koga, Eiichi Ishii, Toshiro Hara

研究成果: Contribution to journalArticle査読

46 被引用数 (Scopus)

抄録

The mRNA contents of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 in leukemia cells from 33 infants with acute lymphoblastic leukemia (ALL) were quantified at initial presentation, and the correlation between their expression and patient clinical characteristics was examined. The mRNA contents of MMP-2 and MMP-9 were not associated with any patient characteristics. Positive correlation was found between hepatosplenomegaly and the MMP-2/TIMP-1 and MMP-2/TIMP-2 ratios (p = 0.005 and 0.009) and between CNS involvement and the MMP-2/TIMP-2 ratio (p = 0.012). The results suggest that MMP/TIMP balance is closely related to the infiltration of leukemia cells into extramedullary organs.

本文言語英語
ページ(範囲)1437-1440
ページ数4
ジャーナルLeukemia Research
31
10
DOI
出版ステータス出版済み - 10 2007

All Science Journal Classification (ASJC) codes

  • 血液学
  • 腫瘍学
  • 癌研究

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