Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats

I. Takahashi, M. Nishimura, K. Onodera, J. W. Bae, H. Mitani, M. Okazaki, Y. Sasano, H. Mitani

研究成果: Contribution to journalArticle査読

76 被引用数 (Scopus)

抄録

Periodontal ligament tissue is remodeled on both the tension and compression sides of moving teeth during orthodontic tooth movement. The present study was designed to clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted during the remodeling of periodontal ligament tissue in orthodontic tooth movement. We used the in situ hybridization method and semi-quantitative reverse-transcription/polymerase chain-reaction analysis to elucidate the gene expression of MMP-8 and MMP-13 mRNA. Expression of MMP-8 and MMP-13 mRNA transiently increased on both the compression and tension sides during active tooth movement in vivo. The gene expression of MMP-8 and MMP-13 was induced by tension, while compression indirectly promoted the gene expression of MMP-8 and MMP-13 through soluble factors in vitro. Thus, we concluded that the expression of MMP-8 and MMP-13 is differentially regulated by tension and compression, and plays an important role in the remodeling of the periodontal ligament.

本文言語英語
ページ(範囲)646-651
ページ数6
ジャーナルJournal of Dental Research
82
8
DOI
出版ステータス出版済み - 8 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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