TY - JOUR
T1 - Expression of SATB2, RUNX2, and SOX9 and possible osteoblastic and chondroblastic differentiation in chondroblastoma
AU - Toda, Yu
AU - Yamamoto, Hidetaka
AU - Iwasaki, Takeshi
AU - Ishihara, Shin
AU - Ito, Yoshihiro
AU - Susuki, Yosuke
AU - Kawaguchi, Kengo
AU - Kinoshita, Izumi
AU - Kiyozawa, Daisuke
AU - Yamada, Yuichi
AU - Kohashi, Kenichi
AU - Kimura, Atsushi
AU - Fujiwara, Toshifumi
AU - Setsu, Nokitaka
AU - Endo, Makoto
AU - Matsumoto, Yoshihiro
AU - Nakashima, Yasuharu
AU - Mawatari, Masaaki
AU - Oda, Yoshinao
N1 - Funding Information:
This study was supported by JSPS KAKENHI Grant Numbers 19H03444 and 21K06887 .
Publisher Copyright:
© 2022 Elsevier GmbH
PY - 2023/1
Y1 - 2023/1
N2 - Chondroblastoma (CB) is histologically characterized by oval to polygonal-shaped mononuclear neoplastic cells, multinucleated osteoclastic giant cells, and eosinophilic matrix with occasional calcification. Genetically, the majority of CBs harbor H3F3B p.K36M mutation. Despite the historical nomenclature, it has been reported that the matrix of CB is similar to osteoid rather than true cartilage; however, it remains unclear whether neoplastic cells in CB have the potential for osteoblastic differentiation. To clarify this issue, we immunohistochemically examined the expression of osteogenic and chondrogenic markers (SATB2, RUNX2, p63, and SOX9) as well as H3K36M mutant protein in 33 cases of CB. All 33 cases of CB were positive for H3K36M, while SATB2, RUNX2, p63, and SOX9 were expressed in 30/33 (91%), 33/33 (100%), 29/33 (88%), and 31/32 (97%) CB cases, respectively. Our immunohistochemical results suggest that neoplastic cells in CB frequently express both osteogenic and chondrogenic markers and may have an intermediate feature of osteoblastic and chondroblastic nature.
AB - Chondroblastoma (CB) is histologically characterized by oval to polygonal-shaped mononuclear neoplastic cells, multinucleated osteoclastic giant cells, and eosinophilic matrix with occasional calcification. Genetically, the majority of CBs harbor H3F3B p.K36M mutation. Despite the historical nomenclature, it has been reported that the matrix of CB is similar to osteoid rather than true cartilage; however, it remains unclear whether neoplastic cells in CB have the potential for osteoblastic differentiation. To clarify this issue, we immunohistochemically examined the expression of osteogenic and chondrogenic markers (SATB2, RUNX2, p63, and SOX9) as well as H3K36M mutant protein in 33 cases of CB. All 33 cases of CB were positive for H3K36M, while SATB2, RUNX2, p63, and SOX9 were expressed in 30/33 (91%), 33/33 (100%), 29/33 (88%), and 31/32 (97%) CB cases, respectively. Our immunohistochemical results suggest that neoplastic cells in CB frequently express both osteogenic and chondrogenic markers and may have an intermediate feature of osteoblastic and chondroblastic nature.
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U2 - 10.1016/j.prp.2022.154239
DO - 10.1016/j.prp.2022.154239
M3 - Article
AN - SCOPUS:85142412737
SN - 0344-0338
VL - 241
JO - Pathology Research and Practice
JF - Pathology Research and Practice
M1 - 154239
ER -