Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear

Takuya Ishibashi, Masaya Takumida, Nana Akagi, Katsuhiro Hirakawa, Matti Anniko

研究成果: ジャーナルへの寄稿学術誌査読

25 被引用数 (Scopus)

抄録

Conclusion. It is suggested that transient receptor potential vanilloids (TRPVs) may play a functional role in cell physiology and TRPV-4 and -2 may play an important part in fluid homeostasis in the inner ear. Objective. Expression of TRPV-1, -2, -3, and -4 in the normal mouse inner ear was studied. Materials and methods. CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated by immunohistochemistry. Results. TRPV-1, -2, and -3 were co-expressed in hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells in vestibular end organs, vestibular ganglion cells, and sensory nerve fibers. TRPV-2 was also detected in the stria vascularis, dark cells, and endolymphatic sac. TRPV-4 was expressed in hair cells and supporting cells of the organ of Corti, in marginal cells of the stria vascularis, spiral ganglion cells, vestibular sensory cells, vestibular dark cells, vestibular ganglion cells, and epithelial cells of the endolymphatic sac.

本文言語英語
ページ(範囲)1286-1293
ページ数8
ジャーナルActa Oto-Laryngologica
128
12
DOI
出版ステータス出版済み - 2008
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 耳鼻咽喉科学

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