Expression of VEGF and its receptor genes in intracranial schwannomas

Toshio Uesaka, Tadahisa Shono, Satoshi O. Suzuki, Akira Nakamizo, Hiroaki Niiro, Masahiro Mizoguchi, Toru Iwaki, Tomio Sasaki

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

抄録

Vascular endothelial growth factor (VEGF) is considered to be a major regulator of angiogenesis in various brain tumors. In this study, we determined the expression levels of VEGF, and vascular endothelial growth factor receptor (VEGFR)-1 and -2 mRNA in 46 intracranial schwannomas by quantitative real-time PCR, and correlated these with various clinical factors or other molecular markers. We found that these tumors expressed significant amounts of VEGF mRNA in comparison with other brain tumors, including malignant gliomas and meningiomas. In addition, we performed immunohistochemical studies for VEGF and VEGFR-1, and confirmed that these tumors prominently express these proteins. The expression levels of VEGF and VEGFR-1 mRNA in recurrent tumors were higher than those in primary tumors. When we divided patients into two groups according to VEGF mRNA expression in the tumor, there was no significant difference in patient age, gender, or cranial nerves of origin between groups; however, the tumor volume tended to be larger in the high VEGF group than in the low VEGF group. The levels of VEGFR-1 mRNA and neurofibromatosis-2 mRNA in the high VEGF group were significantly greater than those in the low VEGF group. Levels of VEGFR-2 mRNA and DNA topoisomerase IIα mRNA, and the MIB-1 labeling index in the high VEGF group were slightly higher than those in the low VEGF group; however, the difference was not statistically significant. Based on these observations, the significance of VEGF and its receptor genes in intracranial schwannomas is discussed.

元の言語英語
ページ(範囲)259-266
ページ数8
ジャーナルJournal of Neuro-Oncology
83
発行部数3
DOI
出版物ステータス出版済み - 7 1 2007

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Vascular Endothelial Growth Factor Receptor
Neurilemmoma
Vascular Endothelial Growth Factor A
Genes
Vascular Endothelial Growth Factor Receptor-1
Messenger RNA
Vascular Endothelial Growth Factor Receptor-2
Neoplasms
Brain Neoplasms
Neurofibromatosis 2
Type II DNA Topoisomerase
Cranial Nerves
Meningioma
Tumor Burden
Glioma
Real-Time Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

これを引用

Expression of VEGF and its receptor genes in intracranial schwannomas. / Uesaka, Toshio; Shono, Tadahisa; Suzuki, Satoshi O.; Nakamizo, Akira; Niiro, Hiroaki; Mizoguchi, Masahiro; Iwaki, Toru; Sasaki, Tomio.

:: Journal of Neuro-Oncology, 巻 83, 番号 3, 01.07.2007, p. 259-266.

研究成果: ジャーナルへの寄稿記事

Uesaka, Toshio ; Shono, Tadahisa ; Suzuki, Satoshi O. ; Nakamizo, Akira ; Niiro, Hiroaki ; Mizoguchi, Masahiro ; Iwaki, Toru ; Sasaki, Tomio. / Expression of VEGF and its receptor genes in intracranial schwannomas. :: Journal of Neuro-Oncology. 2007 ; 巻 83, 番号 3. pp. 259-266.
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