Expression profile of class I histone deacetylases in human cancer tissues

Masamune Nakagawa, Yoshinao Oda, Takashi Eguchi, Shin Ichi Aishima, Takashi Yao, Fumihito Hosoi, Yuji Basaki, Mayumi Ono, Michihiko Kuwano, Masao Tanaka, Masazumi Tsuneyoshi

研究成果: Contribution to journalArticle査読

255 被引用数 (Scopus)

抄録

Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.

本文言語英語
ページ(範囲)769-774
ページ数6
ジャーナルOncology reports
18
4
DOI
出版ステータス出版済み - 10 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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