Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions

Takuya Matsushita, Noriko Isobe, T. Matsuoka, T. Ishizu, Y. Kawano, T. Yoshiura, Y. Ohyagi, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

抄録

Objective: Using neuroimaging, we analyzed the nature of extensive brain lesions in five anti-aquaporin-4 (AQP4) antibody-positive patients with neuromyelitis optica spectrum disorders. Results: Extensive brain lesions involved white matter in three, and basal ganglia and corpus callosum in one each. Four patients showed high diffusivity on apparent diffusion coefficient maps and three demonstrated increased choline/creatine ratios and decreased N-acetyl-aspartate/creatine ratios on 1H-magnetic resonance spectroscopy. These findings suggested that the lesions were vasogenic edema associated with inflammation. Unusual brain symptoms associated with such lesions included recurrent limbic encephalitis, parkinsonism, and coma. Conclusion: Anti-AQP4 antibody is considered to be associated with the neuroimaging appearances of vasogenic edema.

元の言語英語
ページ(範囲)1113-1117
ページ数5
ジャーナルMultiple Sclerosis
15
発行部数9
DOI
出版物ステータス出版済み - 8 28 2009

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Aquaporin 4
Edema
Creatine
Neuroimaging
Antibodies
Brain
Limbic Encephalitis
Neuromyelitis Optica
Corpus Callosum
Parkinsonian Disorders
Coma
Choline
Basal Ganglia
Magnetic Resonance Spectroscopy
Inflammation

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. / Matsushita, Takuya; Isobe, Noriko; Matsuoka, T.; Ishizu, T.; Kawano, Y.; Yoshiura, T.; Ohyagi, Y.; Kira, Jun-Ichi.

:: Multiple Sclerosis, 巻 15, 番号 9, 28.08.2009, p. 1113-1117.

研究成果: ジャーナルへの寄稿記事

Matsushita, Takuya ; Isobe, Noriko ; Matsuoka, T. ; Ishizu, T. ; Kawano, Y. ; Yoshiura, T. ; Ohyagi, Y. ; Kira, Jun-Ichi. / Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. :: Multiple Sclerosis. 2009 ; 巻 15, 番号 9. pp. 1113-1117.
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