External chiral ligand-induced enantioselective lithiation/S(E)2 reactions of isochroman and phthalan

Katsuhiko Tomooka, L. F. Wang, F. Okazaki, T. Nakai

研究成果: ジャーナルへの寄稿記事

49 引用 (Scopus)

抄録

Treatment of isochroman and phthalan with a t-BuLi/chiral bis(oxazoline) complex followed by reaction with carbon-electrophiles such as benzaldehyde and CO2 is shown to afford the α-substituted derivatives in moderate-to-high enantioselectivities (up to 97% ee and 83% ee, respectively). The asymmetric induction is proved to occur at the post-lithiation step. (C) 2000 Elsevier Science Ltd.

元の言語英語
ページ(範囲)6121-6125
ページ数5
ジャーナルTetrahedron Letters
41
発行部数32
DOI
出版物ステータス出版済み - 8 5 2000
外部発表Yes

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Enantioselectivity
Carbon
Ligands
Derivatives
folpet
benzaldehyde

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

これを引用

External chiral ligand-induced enantioselective lithiation/S(E)2 reactions of isochroman and phthalan. / Tomooka, Katsuhiko; Wang, L. F.; Okazaki, F.; Nakai, T.

:: Tetrahedron Letters, 巻 41, 番号 32, 05.08.2000, p. 6121-6125.

研究成果: ジャーナルへの寄稿記事

Tomooka, Katsuhiko ; Wang, L. F. ; Okazaki, F. ; Nakai, T. / External chiral ligand-induced enantioselective lithiation/S(E)2 reactions of isochroman and phthalan. :: Tetrahedron Letters. 2000 ; 巻 41, 番号 32. pp. 6121-6125.
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AU - Nakai, T.

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