Extracellular adenosine 5′-triphosphate-evoked norepinephrine secretion not relating to voltage-gated Ca channels in pheochromocytoma PC12 cells

Kazuhide Inoue, Ken Nakazawa, Kannosuke Fujimori, Akira Takanaka

研究成果: Contribution to journalArticle査読

70 被引用数 (Scopus)

抄録

Characteristics of extracellular ATP-stimulated norepinephrine (NE) secretion were investigated by the batch method in relation to membrane current measured with the whole cell voltage-clamp technique. Extracellular ATP stimulated [3H]NE secretion from PC12 cells in a concentration range from 10 μM to 1 mM. The maximal effect of ATP was about 5 times larger than that of nicotine. ATP-stimulated secretion was extracellular Ca-dependent, but it was not inhibited by the Ca-channel blockers, cadmium (300 μM) or nicardipine (10 μM). Extracellular ATP activated an inward current in PC12 cells and the peak amplitude of the current was about 5 times larger than that activated by nicotine. These findings suggest that extracellular ATP activates receptor-operated channels and causes NE secretion.

本文言語英語
ページ(範囲)294-299
ページ数6
ジャーナルNeuroscience Letters
106
3
DOI
出版ステータス出版済み - 12 4 1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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