F-box proteins and cancer

Kanae Yumimoto, Yuhei Yamauchi, Keiichi I. Nakayama

研究成果: Contribution to journalReview article査読

9 被引用数 (Scopus)

抄録

Controlled protein degradation is essential for the operation of a variety of cellular processes including cell division, growth, and differentiation. Identification of the relations between ubiquitin ligases and their substrates is key to understanding the molecular basis of cancer development and to the discovery of novel targets for cancer therapeutics. F-box proteins function as the substrate recognition subunits of S-phase kinase-associated protein 1 (SKP1)−Cullin1 (CUL1)−F-box protein (SCF) ubiquitin ligase complexes. Here, we summarize the roles of specific Fbox proteins that have been shown to function as tumor promoters or suppressors. We also highlight proto-oncoproteins that are targeted for ubiquitylation by multiple F-box proteins, and discuss how these F-box proteins are deployed to regulate their cognate substrates in various situations.

本文言語英語
論文番号1249
ジャーナルCancers
12
5
DOI
出版ステータス出版済み - 5 2020

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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