Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).
|出版ステータス||出版済み - 10 19 2006|
|イベント||55th SPSJ Annual Meeting - Nagoya, 日本|
継続期間: 5 24 2006 → 5 26 2006
|その他||55th SPSJ Annual Meeting|
|Period||5/24/06 → 5/26/06|
All Science Journal Classification (ASJC) codes