Fabrication and physical evaluation of gelatin-coated carbonate apatite foam

Kanae Hara, Kenji Fujisawa, Hirokazu Nagai, Natsumi Takamaru, Go Ohe, Kanji Tsuru, Kunio Ishikawa, Youji Miyamoto

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.

元の言語英語
記事番号711
ジャーナルMaterials
9
発行部数9
DOI
出版物ステータス出版済み - 9 2016

Fingerprint

Apatite
Gelatin
Foams
Carbonates
Fabrication
Strength of materials
Bone
Heat treatment
carboapatite
Crosslinking
Compressive strength
Swelling
Reinforcement
Sodium Chloride

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

これを引用

Hara, K., Fujisawa, K., Nagai, H., Takamaru, N., Ohe, G., Tsuru, K., ... Miyamoto, Y. (2016). Fabrication and physical evaluation of gelatin-coated carbonate apatite foam. Materials, 9(9), [711]. https://doi.org/10.3390/ma9090711

Fabrication and physical evaluation of gelatin-coated carbonate apatite foam. / Hara, Kanae; Fujisawa, Kenji; Nagai, Hirokazu; Takamaru, Natsumi; Ohe, Go; Tsuru, Kanji; Ishikawa, Kunio; Miyamoto, Youji.

:: Materials, 巻 9, 番号 9, 711, 09.2016.

研究成果: ジャーナルへの寄稿記事

Hara, K, Fujisawa, K, Nagai, H, Takamaru, N, Ohe, G, Tsuru, K, Ishikawa, K & Miyamoto, Y 2016, 'Fabrication and physical evaluation of gelatin-coated carbonate apatite foam', Materials, 巻. 9, 番号 9, 711. https://doi.org/10.3390/ma9090711
Hara K, Fujisawa K, Nagai H, Takamaru N, Ohe G, Tsuru K その他. Fabrication and physical evaluation of gelatin-coated carbonate apatite foam. Materials. 2016 9;9(9). 711. https://doi.org/10.3390/ma9090711
Hara, Kanae ; Fujisawa, Kenji ; Nagai, Hirokazu ; Takamaru, Natsumi ; Ohe, Go ; Tsuru, Kanji ; Ishikawa, Kunio ; Miyamoto, Youji. / Fabrication and physical evaluation of gelatin-coated carbonate apatite foam. :: Materials. 2016 ; 巻 9, 番号 9.
@article{4269afbd0c2541f3b8337ca171473831,
title = "Fabrication and physical evaluation of gelatin-coated carbonate apatite foam",
abstract = "Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass {\%} gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.",
author = "Kanae Hara and Kenji Fujisawa and Hirokazu Nagai and Natsumi Takamaru and Go Ohe and Kanji Tsuru and Kunio Ishikawa and Youji Miyamoto",
year = "2016",
month = "9",
doi = "10.3390/ma9090711",
language = "English",
volume = "9",
journal = "Materials",
issn = "1996-1944",
publisher = "MDPI AG",
number = "9",

}

TY - JOUR

T1 - Fabrication and physical evaluation of gelatin-coated carbonate apatite foam

AU - Hara, Kanae

AU - Fujisawa, Kenji

AU - Nagai, Hirokazu

AU - Takamaru, Natsumi

AU - Ohe, Go

AU - Tsuru, Kanji

AU - Ishikawa, Kunio

AU - Miyamoto, Youji

PY - 2016/9

Y1 - 2016/9

N2 - Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.

AB - Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.

UR - http://www.scopus.com/inward/record.url?scp=84988983311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988983311&partnerID=8YFLogxK

U2 - 10.3390/ma9090711

DO - 10.3390/ma9090711

M3 - Article

AN - SCOPUS:84988983311

VL - 9

JO - Materials

JF - Materials

SN - 1996-1944

IS - 9

M1 - 711

ER -