Fabrication of a ring structure at the aperture of a hole for the efficient suspension of a lipid bilayer

Toichiro Goto, Yuichi Harada, David Cox, Koji Sumitomo

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

We propose a hydrophilic-raised-ring structure at the aperture of a hole for the efficient suspension of a lipid bilayer. This ring structure can be fabricated by using a combination consisting of a focused ion beam (FIB) and a hydrogen silsesquioxane (HSQ) negative electron beam (EB) resist layer on a substrate. Negative EB resist at the aperture of a hole can be selectively reacted with a scattered gallium ion beam during the FIB milling process, and a ring structure can be obtained by employing a development process. Assessments of the cross section of the ring revealed a two-step structure. The suspension of lipid bilayers on the ring structures was assessed by observing the green fluorescence of calcein dye inside the holes. Our observation of fluorescent images showed that the lipid bilayers on the ring structures sealed the calcein solutions. This result indicates that our fabrication processes can be used to produce nanobio devices that need lipid bilayer suspensions.

本文言語英語
論文番号96503
ジャーナルJapanese journal of applied physics
53
9
DOI
出版ステータス出版済み - 2014
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 工学(全般)
  • 物理学および天文学(全般)

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