Fabrication of biodegradable particles for DDS by self-organized precipitation method

Daisuke Ohsato, Takeshi Higuchi, Hiroshi Yabu, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

研究成果: 会議への寄与タイプ論文


Recently, we have reported the formation of nano-particles by mixing a poor solvent into a solution of polymer, and then evaporating a good solvent. In this report, nano-particles were prepared from various biodegradable polymers. Average size of the particles was measured by dynamic light scattering spectrophotometer. The particles were observed by Field-Emission Scanning Electron Microscopy. Uniform sized particles were formed. The particle size was controlled ranging from 100 nm to 1000 nm. In the case of Poly(ε- caprolactone)(PCL), the particle size became larger with increasing the concentration of solution, and increasing the volume ratio of a good solvent / a poor solvent. Fabrication of biodegradable particles containing a drug and their concentration of drug in the particles will be reported.

出版物ステータス出版済み - 12 1 2005
イベント54th SPSJ Annual Meeting 2005 - Yokohama, 日本
継続期間: 5 25 20055 27 2005


その他54th SPSJ Annual Meeting 2005


All Science Journal Classification (ASJC) codes

  • Engineering(all)


Ohsato, D., Higuchi, T., Yabu, H., Tanaka, M., Yamamoto, S., & Shimomura, M. (2005). Fabrication of biodegradable particles for DDS by self-organized precipitation method. 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, 日本.