Fabrication of carbonate apatite-PLGA hybrid foam bone substitute

Girlie M. Munar, Melvin L. Munar, Kanji Tsuru, Shigeki Matsuya, Kunio Ishikawa

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Porous carbonate apatite (CO3AP) foam is a potential bone substitute material since it approximates the morphology and mineral phase of bone. One drawback however, is the poor mechanical properties for sufficient handling. A useful method to improve the mechanical property is by reinforcing it with biodegradable polymer. This study reports the preparation of carbonate apatite-PLGA (CO3AP-PLGA) hybrid foam with improved mechanical strength and osteoconductivity. CO3AP foam was prepared by hydrothermal treatment of α-tricalcium phosphate (αTCP) foam in carbonate solution at 150°C for 24 hours. CO3AP powder was synthesized from vaterite (CaCO3) and disodium hydrogen phosphate (Na2HPO4) aqueous solution at 37°C. The obtained CO3AP powder was mixed with 10wt% PLGA solution then reinforced on CO3AP foam using freeze-vacuum technique. The obtained CO 3AP-PLGA hybrid foam showed interconnecting porous structure with average porosity of 85%. Compressive strength of CO3Ap-PLGA hybrid foam was as high as 0.35 MPa when compared to that of CO3Ap foam at 0.01 MPa. X-ray diffraction and FT-IR showed CO3Ap as the primary mineral phase. In conclusion, CO3AP-PLGA hybrid foam with improved mechanical properties and approximates the mineral composition and morphology of the cancellous bone can be a potential bone substitute or scaffold for tissue engineering.

本文言語英語
ホスト出版物のタイトルAdvances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012
ページ75-78
ページ数4
6
出版ステータス出版済み - 4 8 2013
イベントAdvances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012 - Daytona Beach, FL, 米国
継続期間: 1 22 20121 27 2012

出版物シリーズ

名前Ceramic Engineering and Science Proceedings
番号6
33
ISSN(印刷版)0196-6219

その他

その他Advances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012
Country米国
CityDaytona Beach, FL
Period1/22/121/27/12

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Materials Chemistry

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