Fabrication of interconnected porous calcite by bridging calcite granules with dicalcium phosphate dihydrate and their histological evaluation

Kunio Ishikawa, Noriko Koga, Kanji Tsuru, Ichiro Takahashi

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

Interconnected porous calcite has attracted attention as an artificial bone replacement material and as a precursor for the fabrication of carbonate apatite, which is also an artificial bone replacement material. In this study, calcite granules were exposed to acidic calcium phosphate solution, and the feasibility of fabricating interconnected porous calcite using this process was evaluated. No setting reaction was observed under the nonloading condition. In contrast, under loading conditions, calcite granules were bridged with dicalcium phosphate dihydrate crystals, and the calcite granules set into interconnected porous calcite foam. When applied 0.4 MPa of loading pressure during sample preparation, compressive strength of the obtained interconnected porous calcite was ∼1.5 MPa. The exposure of the calcite granules to acidic calcium phosphate solution under loading conditions was the key for the setting reaction to occur. This is because calcite granules cannot contact one another under the nonloading condition because of bubble formation on the surfaces of the calcite granules. The interconnected porous calcite revealed excellent tissue response, and new bone was able to penetrate into the porous calcite 2 weeks after implantation.

本文言語英語
ページ(範囲)652-658
ページ数7
ジャーナルJournal of Biomedical Materials Research - Part A
104
3
DOI
出版ステータス出版済み - 3 1 2016

All Science Journal Classification (ASJC) codes

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金

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