Spherical carbonate apatite (CO 3Ap) microspheres approximately 1 mm in diameter were fabricated by granulation of calcium hydroxide around a core followed by carbonation and phosphatization through dissolution-precipitation reaction. CO 3Ap microspheres with high uniformity could not be achieved without using a core. Solid CO 3Ap microspheres were obtained using a calcite core whereas hollow CO 3Ap microspheres were obtained using a NaCl core. The obtained microsphere was identified as B-type CO 3Ap by Fourier transform infrared analysis and the carbonate content was approximately 7-8 wt% regardless of the type of core used for sample preparation. The mechanical strength of both the solid and hollow CO 3Ap microspheres was sufficient for practical use as a bone substitute.
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