Fabrication of strongly attached hydroxyapatite coating on titanium by hydrothermal treatment of Ti–Zn–PO4 coated titanium in CaCl2 solution

Alireza Valanezhad, Kanji Tsuru, Kunio Ishikawa

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)


Abstract: Hydroxyapatite (HAp) coating was formed on zinc phosphate (Ti–Zn–PO4) coated Ti plates by hydrothermal treatment in CaCl2 solution at 200 °C for 12 h. Uniform surface coverage of the fabricated HAp coating was obtained by this method. SEM-EDX analysis of the adhesion test area showed that the presence of fractures only occurred in HAp crystals. On the other words cohesive fracture was seen in HAp coating layer formed on the Ti–Zn–PO4. The measured strength was around 42.3 ± 17 MPa. Rat bone marrow (RBM) mesenchymal stem cells were cultured and differentiation-induced on each sample (Ti plate, Ti–Zn–PO4 coated and HAp coated), and cell calcification properties were examined. Apparent differences in morphology and extension of the RBM cells were obtained, while the Ti–Zn–PO4 coated samples showed the highest cell number among all samples. After differentiation-induction, HAp coated samples showed the highest amount of alkaline phosphatase activity, and the highest level of cell calcification. Therefore, the hard tissue compatibility of Ti is improved by hydrothermally HAp coating of samples. Graphical abstract: [Figure not available: see fulltext.]

ジャーナルJournal of Materials Science: Materials in Medicine
出版ステータス出版済み - 7 25 2015

All Science Journal Classification (ASJC) codes

  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学


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