Facile enantiomer analysis by combination of N-dansyl amino acid as diastereomerizer and molecular-shape recognitive RP-HPLC using comb-shaped polymer-immobilized silica

H. Ihara, M. Takafuji, T. Sakurai, H. Tsukamoto, A. Shundo, T. Sagawa, S. Nagaoka

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Poly(octadecyl acrylate)-grafted silica has been developed as a special stationary phase showing molecular-shape recognition in high-performance liquid chromatography. The bonded polymer phase is characterized by the fact that the polymer forms highly-ordered structures similar to a solvated crystalline state on silica and multiple π-π interaction between carbonyl groups in the polymer and aromatic solutes is promoted. This paper shows that the selectivity for DL-amino acids diastereomerized with N-dansyl L-proline can be enhanced by using the polymer stationary phase instead of octadecylated silica (ODS).

本文言語英語
ページ(範囲)2561-2572
ページ数12
ジャーナルJournal of Liquid Chromatography and Related Technologies
27
16
DOI
出版ステータス出版済み - 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 薬科学
  • 臨床生化学

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