Facilitating the presentation of antigen peptides on dendritic cells for cancer immunotherapy using a polymer-based synthetic receptor

Cuicui Li, Masafumi Takeo, Masayoshi Matsuda, Hiroko Nagai, Sun Xizheng, Wataru Hatanaka, Akihiro Kishimura, Hiroyuki Inoue, Kenzaburo Tani, Takeshi Mori, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

抄録

The introduction of proteins into dendritic cells (DCs) ex vivo is a critical step for the DC-based immunotherapy of cancer. Here, we developed a biotin-modified polymer with multiple hydrophobic membrane anchors for cells that functions as a synthetic receptor for an antigen protein, ovalbumin (OVA), to introduce it efficiently into DCs compared with the conventional pulsing method. Our method showed significant advantages, including the rapid incorporation of OVA and the activation of antigen-specific T cells in a MHC-restricted manner. When mice were immunized by DCs treated with our method, tumor growth was completely suppressed, indicating that our method can be used to prepare adjuvant DCs.

元の言語英語
ページ(範囲)1207-1212
ページ数6
ジャーナルMedChemComm
8
発行部数6
DOI
出版物ステータス出版済み - 1 1 2017

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Artificial Receptors
Antigen Presentation
Immunotherapy
Dendritic Cells
Polymers
Antigens
Peptides
Ovalbumin
Neoplasms
CD27 Antigens
Synthetic Vaccines
T-cells
Biotin
Anchors
Tumors
Proteins
Chemical activation
Cell Membrane
Membranes
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmaceutical Science

これを引用

Facilitating the presentation of antigen peptides on dendritic cells for cancer immunotherapy using a polymer-based synthetic receptor. / Li, Cuicui; Takeo, Masafumi; Matsuda, Masayoshi; Nagai, Hiroko; Xizheng, Sun; Hatanaka, Wataru; Kishimura, Akihiro; Inoue, Hiroyuki; Tani, Kenzaburo; Mori, Takeshi; Katayama, Yoshiki.

:: MedChemComm, 巻 8, 番号 6, 01.01.2017, p. 1207-1212.

研究成果: ジャーナルへの寄稿記事

Li, Cuicui ; Takeo, Masafumi ; Matsuda, Masayoshi ; Nagai, Hiroko ; Xizheng, Sun ; Hatanaka, Wataru ; Kishimura, Akihiro ; Inoue, Hiroyuki ; Tani, Kenzaburo ; Mori, Takeshi ; Katayama, Yoshiki. / Facilitating the presentation of antigen peptides on dendritic cells for cancer immunotherapy using a polymer-based synthetic receptor. :: MedChemComm. 2017 ; 巻 8, 番号 6. pp. 1207-1212.
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AU - Xizheng, Sun

AU - Hatanaka, Wataru

AU - Kishimura, Akihiro

AU - Inoue, Hiroyuki

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AU - Mori, Takeshi

AU - Katayama, Yoshiki

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