Factors affecting surgical outcome for gallbladder carcinoma

Hirokazu Noshiro, Kazuo Chijiiwa, Koji Yamaguchi, Syuji Shimizu, Atsushi Sugitani, Masao Tanaka

研究成果: Contribution to journalReview article査読

18 被引用数 (Scopus)

抄録

Background/Aims: The outcome of advanced gallbladder carcinoma is dismal despite aggressive surgery. The aim of this study was to evaluate the surgical outcome and prognostic factors for patients with gallbladder carcinoma and to identify patients who may benefit from radical surgery. Methodology: Fifty-six patients who underwent surgical resection of gallbladder carcinoma were retrospectively reviewed. Their tumor markers, operative management, pathological factors and survival were analyzed. Results: The serum carcinoembryonic antigen level was elevated in 9 of 51 patients (18%) with data available as was the serum carbohydrate antigen 19-9 level in 14 of 47 patients (30%). Univariate analysis showed that jaundice, serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels, the number, size, macroscopic type, and histological grade of the tumor, the depth of tumor invasion (pT), pathological stage, lymph node metastasis (pN), lymphatic invasion, vascular invasion, perineural infiltration, curability of lymph node dissection and surgical margins have prognostic significance for survival. Multivariate analysis revealed jaundice, high histological grade, pT3 or pT4, and surgical margins were independent prognostic factors for survival. Conclusions: Preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels are potential predictors and informative for survival. There are still difficulties to treat gallbladder carcinoma infiltrating beyond subserosa or revealing jaundice.

本文言語英語
ページ(範囲)939-944
ページ数6
ジャーナルHepato-gastroenterology
50
52
出版ステータス出版済み - 7 2003

All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 消化器病学

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