Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture

Makoto Yanagisawa, Kinichi Nakashima, Wataru Ochiai, Takumi Takizawa, Takao Setoguchi, Atsumi Uemura, Makiko Takizawa, Ikuo Nobuhisa, Tetsuya Taga

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Mammalian cells that have been committed to a certain cell lineage cannot be directed to other lineages. However, some astrocytes in the mammalian brains have been reported to represent plasticity to redirect to other cell lineages. We found that mouse hippocampal astrocytes cultured in aggregate forms of "astrosphere", redirected to MAP2-positive immature neurons. In astrospheres, basic HLH factors positively regulating neuronal differentiation were up-regulated and Id3 inhibiting basic HLH factors was down-regulated. Ectopic Id3 induction repressed redirection of astrocytes to a neuronal lineage, suggesting that astrosphere formation induced plasticity of astrocytes by changing the gene expression patterns.

本文言語英語
ページ(範囲)176-182
ページ数7
ジャーナルNeuroscience Research
53
2
DOI
出版ステータス出版済み - 10 1 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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