Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Hirobumi Tada, Hirotaka James Okano, Hiroshi Takagi, Shinsuke Shibata, Ikuko Yao, Masaki Matsumoto, Toru Saiga, Keiichi I. Nakayama, Haruo Kashima, Takuya Takahashi, Mitsutoshi Setou, Hideyuki Okano

研究成果: ジャーナルへの寄稿記事

45 引用 (Scopus)

抄録

Neurons communicate with each other through synapses. To establish the precise yet flexible connections that make up neural networks in the brain, continuous synaptic modulation is required. The ubiquitin-proteasome system of protein degradation is one of the critical mechanisms that underlie this process, playing crucial roles in the regulation of synaptic structure and function. We identified a novel ubiquitin ligase, Fbxo45, that functions at synapses. Fbxo45 is evolutionarily conserved and selectively expressed in the nervous system. We demonstrated that the knockdown of Fbxo45 in primary cultured hippocampal neurons resulted in a greater frequency of miniature excitatory postsynaptic currents. We also found that Fbxo45 induces the degradation of a synaptic vesicle-priming factor, Munc13-1.We propose that Fbxo45 plays an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse.

元の言語英語
ページ(範囲)3840-3849
ページ数10
ジャーナルJournal of Biological Chemistry
285
発行部数6
DOI
出版物ステータス出版済み - 2 5 2010

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Ligases
Ubiquitin
Synapses
Neurons
Degradation
Neurology
Proteasome Endopeptidase Complex
Brain
Synaptic Vesicles
Excitatory Postsynaptic Potentials
Modulation
Neural networks
Synaptic Transmission
Nervous System
Proteolysis
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Tada, H., Okano, H. J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., ... Okano, H. (2010). Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. Journal of Biological Chemistry, 285(6), 3840-3849. https://doi.org/10.1074/jbc.M109.046284

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. / Tada, Hirobumi; Okano, Hirotaka James; Takagi, Hiroshi; Shibata, Shinsuke; Yao, Ikuko; Matsumoto, Masaki; Saiga, Toru; Nakayama, Keiichi I.; Kashima, Haruo; Takahashi, Takuya; Setou, Mitsutoshi; Okano, Hideyuki.

:: Journal of Biological Chemistry, 巻 285, 番号 6, 05.02.2010, p. 3840-3849.

研究成果: ジャーナルへの寄稿記事

Tada, H, Okano, HJ, Takagi, H, Shibata, S, Yao, I, Matsumoto, M, Saiga, T, Nakayama, KI, Kashima, H, Takahashi, T, Setou, M & Okano, H 2010, 'Fbxo45, a novel ubiquitin ligase, regulates synaptic activity', Journal of Biological Chemistry, 巻. 285, 番号 6, pp. 3840-3849. https://doi.org/10.1074/jbc.M109.046284
Tada, Hirobumi ; Okano, Hirotaka James ; Takagi, Hiroshi ; Shibata, Shinsuke ; Yao, Ikuko ; Matsumoto, Masaki ; Saiga, Toru ; Nakayama, Keiichi I. ; Kashima, Haruo ; Takahashi, Takuya ; Setou, Mitsutoshi ; Okano, Hideyuki. / Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. :: Journal of Biological Chemistry. 2010 ; 巻 285, 番号 6. pp. 3840-3849.
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