Feasibility and outcomes of fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: A Japanese experience

Seiji Wada, Katsusuke Ozawa, Rika Sugibayashi, Fumio Suyama, Shoichiro Amari, Yushi Ito, Yutaka Kanamori, Hiroomi Okuyama, Noriaki Usui, Jun Sasahara, Tomomi Kotani, Masahiro Hayakawa, Kiyoko Kato, Tomoaki Taguchi, Masayuki Endo, Haruhiko Sago

研究成果: Contribution to journalArticle査読

抄録

Aim: To present the feasibility, safety and outcomes of fetoscopic endoluminal tracheal occlusion (FETO) for the treatment of severe congenital diaphragmatic hernia (CDH). Methods: This was a single-arm clinical trial of FETO for isolated left-sided CDH with liver herniation and Kitano Grade 3 stomach position (>50% stomach herniation into the right chest). FETO was performed at 27–29 weeks of gestation for cases with observed/expected lung to head ratio (o/e LHR) <25% and at 30–31 weeks for cases with o/e LHR ≥25%. Results: Eleven cases were enrolled between March 2014 and March 2016, and balloon insertion was successful in all cases. The median o/e LHR at entry was 27% (range, 20–33%). The median gestational age at FETO was 30.9 (range, 27.1–31.7) weeks. There were no severe maternal adverse events. One fetus died unexpectedly at 33 weeks of gestation due to cord strangulation by the detached amniotic membrane. There were 3 cases (27%) of preterm premature rupture of membranes. In all 10 cases, balloon removal at 34–35 weeks of gestation was successful. The median gestational age at delivery was 36.5 (range, 34.2–38.3) weeks. The median duration of occlusion and the median interval between balloon insertion and delivery were 26 days (range: 17–49 days) and 43 days (range, 21–66 days), respectively. Both the survival rate at 90 days of age and the rate of survival to discharge were 45% (5/11). Conclusion: The FETO is feasible without maternal morbidity in Japan and could be offered to women whose fetuses show severe isolated left-sided CDH to accelerate fetal lung growth.

本文言語英語
ページ(範囲)2598-2604
ページ数7
ジャーナルJournal of Obstetrics and Gynaecology Research
46
12
DOI
出版ステータス出版済み - 12 2020

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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