Feasibility of magnetic resonance redox imaging at low magnetic field

Comparison at 1 T and 7 T

Mizuki Nakamura, Sayaka Shibata, Toshihide Yamasaki, Megumi Ueno, Ikuo Nakanishi, Ken Ichiro Matsumoto, Tadashi Kamada, Ken-Ichi Yamada, Ichio Aoki

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.

元の言語英語
記事番号AJTR0054131
ページ(範囲)4481-4491
ページ数11
ジャーナルAmerican Journal of Translational Research
9
発行部数10
出版物ステータス出版済み - 1 1 2017

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Magnetic resonance
Magnetic Fields
Oxidation-Reduction
Magnetic Resonance Imaging
Magnetic fields
Imaging techniques
Experiments
Signal detection
Magnetic resonance imaging
Contrast Media
Noise
Brain
Animals
nitroxyl
Fluxes
Scanning

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

これを引用

Nakamura, M., Shibata, S., Yamasaki, T., Ueno, M., Nakanishi, I., Matsumoto, K. I., ... Aoki, I. (2017). Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T. American Journal of Translational Research, 9(10), 4481-4491. [AJTR0054131].

Feasibility of magnetic resonance redox imaging at low magnetic field : Comparison at 1 T and 7 T. / Nakamura, Mizuki; Shibata, Sayaka; Yamasaki, Toshihide; Ueno, Megumi; Nakanishi, Ikuo; Matsumoto, Ken Ichiro; Kamada, Tadashi; Yamada, Ken-Ichi; Aoki, Ichio.

:: American Journal of Translational Research, 巻 9, 番号 10, AJTR0054131, 01.01.2017, p. 4481-4491.

研究成果: ジャーナルへの寄稿記事

Nakamura, M, Shibata, S, Yamasaki, T, Ueno, M, Nakanishi, I, Matsumoto, KI, Kamada, T, Yamada, K-I & Aoki, I 2017, 'Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T', American Journal of Translational Research, 巻. 9, 番号 10, AJTR0054131, pp. 4481-4491.
Nakamura M, Shibata S, Yamasaki T, Ueno M, Nakanishi I, Matsumoto KI その他. Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T. American Journal of Translational Research. 2017 1 1;9(10):4481-4491. AJTR0054131.
Nakamura, Mizuki ; Shibata, Sayaka ; Yamasaki, Toshihide ; Ueno, Megumi ; Nakanishi, Ikuo ; Matsumoto, Ken Ichiro ; Kamada, Tadashi ; Yamada, Ken-Ichi ; Aoki, Ichio. / Feasibility of magnetic resonance redox imaging at low magnetic field : Comparison at 1 T and 7 T. :: American Journal of Translational Research. 2017 ; 巻 9, 番号 10. pp. 4481-4491.
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abstract = "The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.",
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