Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network

Konosuke Asanou, Naoaki Ono, Chika Iwamoto, Kenoki Ohuchida, Koji Shindo, Shigehiko Kanaya

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

In recent years, computer-aided diagnosis based on machine learning, mainly based on Convolutional Neural Network (CNN) has been studied and developed rapidly. Those methods are not only helpful for classification, but also useful for feature extraction from given images, especially encoding image data into discrete representation helps us obtain new knowledge. Previous researches showed that CNN can by trainded for not only dection of cancers but also classification of gene expression subtypes. Although most of these studies are based on supervised learning that needs curated pathological knowledge, it is useful to extract characteristic features in the given images, using unsupervised machine learning in order to obtain new pathological findings. We applied cluster analysis using CNN which is trained based on adversarial training and maximization of mutual information and showed that it can classify those pathological images into discrete categories. Next, we applied our model for comparison of the two staining method in order to evaluate the degree of malignancy according to fibrosis and cell differentiation. The results showed that encoding of the histopathological image into discrete representations helps us to interpret tumor images.

本文言語英語
ホスト出版物のタイトルProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
編集者Huiru Zheng, Zoraida Callejas, David Griol, Haiying Wang, Xiaohua Hu, Harald Schmidt, Jan Baumbach, Julie Dickerson, Le Zhang
出版社Institute of Electrical and Electronics Engineers Inc.
ページ2738-2740
ページ数3
ISBN(電子版)9781538654880
DOI
出版ステータス出版済み - 1 21 2019
イベント2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, スペイン
継続期間: 12 3 201812 6 2018

出版物シリーズ

名前Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

会議

会議2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
国/地域スペイン
CityMadrid
Period12/3/1812/6/18

All Science Journal Classification (ASJC) codes

  • 生体医工学
  • 健康情報学

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