Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network

Konosuke Asanou, Naoaki Ono, Chika Iwamoto, Kenoki Ouchida, Koji Shindo, Shigehiko Kanayak

研究成果: 著書/レポートタイプへの貢献会議での発言

抄録

In recent years, computer-aided diagnosis based on machine learning, mainly based on Convolutional Neural Network (CNN) has been studied and developed rapidly. Those methods are not only helpful for classification, but also useful for feature extraction from given images, especially encoding image data into discrete representation helps us obtain new knowledge. Previous researches showed that CNN can by trainded for not only dection of cancers but also classification of gene expression subtypes. Although most of these studies are based on supervised learning that needs curated pathological knowledge, it is useful to extract characteristic features in the given images, using unsupervised machine learning in order to obtain new pathological findings. We applied cluster analysis using CNN which is trained based on adversarial training and maximization of mutual information and showed that it can classify those pathological images into discrete categories. Next, we applied our model for comparison of the two staining method in order to evaluate the degree of malignancy according to fibrosis and cell differentiation. The results showed that encoding of the histopathological image into discrete representations helps us to interpret tumor images.

元の言語英語
ホスト出版物のタイトルProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
編集者Harald Schmidt, David Griol, Haiying Wang, Jan Baumbach, Huiru Zheng, Zoraida Callejas, Xiaohua Hu, Julie Dickerson, Le Zhang
出版者Institute of Electrical and Electronics Engineers Inc.
ページ2738-2740
ページ数3
ISBN(電子版)9781538654880
DOI
出版物ステータス出版済み - 1 21 2019
イベント2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, スペイン
継続期間: 12 3 201812 6 2018

出版物シリーズ

名前Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

会議

会議2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
スペイン
Madrid
期間12/3/1812/6/18

Fingerprint

Cluster analysis
Cluster Analysis
Feature extraction
Neural networks
Learning systems
Computer aided diagnosis
Neoplasms
Supervised learning
Gene expression
Tumors
Cell Differentiation
Fibrosis
Learning
Staining and Labeling
Gene Expression
Research

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics

これを引用

Asanou, K., Ono, N., Iwamoto, C., Ouchida, K., Shindo, K., & Kanayak, S. (2019). Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. : H. Schmidt, D. Griol, H. Wang, J. Baumbach, H. Zheng, Z. Callejas, X. Hu, J. Dickerson, ... L. Zhang (版), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 (pp. 2738-2740). [8621323] (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2018.8621323

Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. / Asanou, Konosuke; Ono, Naoaki; Iwamoto, Chika; Ouchida, Kenoki; Shindo, Koji; Kanayak, Shigehiko.

Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. 版 / Harald Schmidt; David Griol; Haiying Wang; Jan Baumbach; Huiru Zheng; Zoraida Callejas; Xiaohua Hu; Julie Dickerson; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. p. 2738-2740 8621323 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

研究成果: 著書/レポートタイプへの貢献会議での発言

Asanou, K, Ono, N, Iwamoto, C, Ouchida, K, Shindo, K & Kanayak, S 2019, Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. : H Schmidt, D Griol, H Wang, J Baumbach, H Zheng, Z Callejas, X Hu, J Dickerson & L Zhang (版), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018., 8621323, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Institute of Electrical and Electronics Engineers Inc., pp. 2738-2740, 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Madrid, スペイン, 12/3/18. https://doi.org/10.1109/BIBM.2018.8621323
Asanou K, Ono N, Iwamoto C, Ouchida K, Shindo K, Kanayak S. Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. : Schmidt H, Griol D, Wang H, Baumbach J, Zheng H, Callejas Z, Hu X, Dickerson J, Zhang L, 編集者, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Institute of Electrical and Electronics Engineers Inc. 2019. p. 2738-2740. 8621323. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). https://doi.org/10.1109/BIBM.2018.8621323
Asanou, Konosuke ; Ono, Naoaki ; Iwamoto, Chika ; Ouchida, Kenoki ; Shindo, Koji ; Kanayak, Shigehiko. / Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. 編集者 / Harald Schmidt ; David Griol ; Haiying Wang ; Jan Baumbach ; Huiru Zheng ; Zoraida Callejas ; Xiaohua Hu ; Julie Dickerson ; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 2738-2740 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).
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