Fetal germinal matrix and intraventricular hemorrhage

Takato Morioka, Kimiaki Hashiguchi, Shinji Nagata, Yasushi Miyagi, Futoshi Mihara, Shunji Hikino, Kiyomi Tsukimori, Tomio Sasaki

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)


Subependymal germinal matrix with intraventricular hemorrhage (GMIVH) is a common complication associated with delivery in preterm neonates but has rarely been observed in the fetus. Clinical and neuroradiological findings of 5 patients who were diagnosed as having fetal GMIVH with prenatal ultrasonographic examinations (US) and MRI, and postnatal MRI were reviewed retrospectively. During a seemingly uneventful pregnancy, fetal GMIVH occurred at approximately 30-33 weeks of gestation, with the absence of any known factor predisposing to fetal hemorrhage. Routine obstetric US revealed an intraventricular lesion in the enlarged ventricles. Prenatal MRI clearly demonstrated parenchymal change such as intracerebral hematoma adjacent to the subependymal and intraventricular hematoma, and periventricular leukomalacia as well as GMIVH. Although patients without parenchymal destruction (hemosiderin deposit alone) had a favorable neurodevelopmental outcome, encephalomalacia and periventricular leukomalacia contributed to long-term neurodevelopmental deficits. Evaluating parenchymal damage with prenatal MRI can therefore help to predict neurodevelopmental prognosis of the fetus with GMIVH.

ジャーナルPediatric Neurosurgery
出版ステータス出版済み - 10 2006

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 外科
  • 臨床神経学


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