Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer

Akihide Kamiya, Taisei Kinoshita, Yoshiaki Ito, Takaaki Matsui, Yoshihiro Morikawa, Emiko Senba, Kinichi Nakashima, Tetsuya Taga, Kanji Yoshida, Tadamitsu Kishimoto, Atsushi Miyajima

研究成果: ジャーナルへの寄稿記事

317 引用 (Scopus)

抄録

Fetal liver, the major site of hematopoiesis during embryonic development, acquires additional various metabolic functions near birth. Although liver development has been characterized biologically as consisting of several distinct steps, the molecular events accompanying this process are just beginning to be characterized. In this study, we have established a novel culture system of fetal murine hepatocytes and investigated factors required for development of hepatocytes. We found that oncostatin M (OSM), an interleukin-6 family cytokine, in combination with glucocorticoid, induced maturation of hepatocytes as evidenced by morphological changes that closely resemble more differentiated hepatocytes, expression of hepatic differentiation markers and intracellular glycogen accumulation. Consistent with these in vitro observations, livers from mice deficient for gp130, an OSM receptor subunit, display defects in maturation of hepatocytes. Interestingly, OSM is expressed in CD45+ hematopoietic cells in the developing liver, whereas the OSM receptor is expressed predominantly in hepatocytes. These results suggest a paracrine mechanism of hepatogenesis; blood cells, transiently expanding in the fetal liver, produce OSM to promote development of hepatocytes in vivo.

元の言語英語
ページ(範囲)2127-2136
ページ数10
ジャーナルEMBO Journal
18
発行部数8
出版物ステータス出版済み - 4 15 1999
外部発表Yes

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Cytokine Receptor gp130
Oncostatin M
Fetal Development
Liver
Hepatocytes
Oncostatin M Receptors
Differentiation Antigens
Hematopoiesis
Glycogen
Glucocorticoids
Embryonic Development
Interleukin-6
Blood Cells
Blood
Display devices
Cells
Parturition
Cytokines
Defects

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

これを引用

Kamiya, A., Kinoshita, T., Ito, Y., Matsui, T., Morikawa, Y., Senba, E., ... Miyajima, A. (1999). Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO Journal, 18(8), 2127-2136.

Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. / Kamiya, Akihide; Kinoshita, Taisei; Ito, Yoshiaki; Matsui, Takaaki; Morikawa, Yoshihiro; Senba, Emiko; Nakashima, Kinichi; Taga, Tetsuya; Yoshida, Kanji; Kishimoto, Tadamitsu; Miyajima, Atsushi.

:: EMBO Journal, 巻 18, 番号 8, 15.04.1999, p. 2127-2136.

研究成果: ジャーナルへの寄稿記事

Kamiya, A, Kinoshita, T, Ito, Y, Matsui, T, Morikawa, Y, Senba, E, Nakashima, K, Taga, T, Yoshida, K, Kishimoto, T & Miyajima, A 1999, 'Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer', EMBO Journal, 巻. 18, 番号 8, pp. 2127-2136.
Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E その他. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO Journal. 1999 4 15;18(8):2127-2136.
Kamiya, Akihide ; Kinoshita, Taisei ; Ito, Yoshiaki ; Matsui, Takaaki ; Morikawa, Yoshihiro ; Senba, Emiko ; Nakashima, Kinichi ; Taga, Tetsuya ; Yoshida, Kanji ; Kishimoto, Tadamitsu ; Miyajima, Atsushi. / Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. :: EMBO Journal. 1999 ; 巻 18, 番号 8. pp. 2127-2136.
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AU - Morikawa, Yoshihiro

AU - Senba, Emiko

AU - Nakashima, Kinichi

AU - Taga, Tetsuya

AU - Yoshida, Kanji

AU - Kishimoto, Tadamitsu

AU - Miyajima, Atsushi

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