Fibrodysplasia ossificans progressiva: Review and research activities in Japan

Nobuhiko Haga, Yasuharu Nakashima, Hiroshi Kitoh, Junji Kamizono, Takenobu Katagiri, Hideto Saijo, Sho Tsukamoto, Yusuke Shinoda, Ryoko Sawada, Yasuo Nakahara

研究成果: ジャーナルへの寄稿評論記事

抜粋

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic skeletal disorder manifesting progressive heterotopic ossification (HO) and congenital malformation of the great toes. Since 2007, we have conducted research on FOP. Here, we review the findings on FOP published to date, including the results of our research. Epidemiological studies in Japan have indicated that FOP has nearly the same prevalence in Japan as in the rest of the world. Basic research on its pathoetiology has progressed rapidly since the identification of the causal gene in 2006. Clinical and radiological findings have been thoroughly researched, including early radiological signs, and diagnostic criteria were established, designating FOP as an intractable disease in Japan. In patients with FOP, the progression of HO is associated with numerous disabilities, often manifesting in vicious cycles that can lead to early mortality. Through cross-sectional and short-term longitudinal studies, we have explored patient education, quality of life, and activities of daily living among Japanese patients. The management of FOP requires education of patients and caregivers, the use of medications to settle inflammation and flare-ups, instructions to ensure proper oral care, and other compensatory approaches that aid in rehabilitation. An avoidance of medical intervention, which may cause HO to progress, is also important. The advent of new drugs to prevent HO could have clinical benefit.

元の言語英語
ページ(範囲)3-13
ページ数11
ジャーナルPediatrics International
62
発行部数1
DOI
出版物ステータス出版済み - 1 1 2020

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

これを引用

Haga, N., Nakashima, Y., Kitoh, H., Kamizono, J., Katagiri, T., Saijo, H., ... Nakahara, Y. (2020). Fibrodysplasia ossificans progressiva: Review and research activities in Japan. Pediatrics International, 62(1), 3-13. https://doi.org/10.1111/ped.14065