First Functionalized MRI Contrast Agent Recognizing Vascular Lesions

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MR1. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.

元の言語英語
ページ(範囲)5-7
ページ数3
ジャーナルanalytical sciences
20
発行部数1
DOI
出版物ステータス出版済み - 1 2004

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Magnetic resonance imaging
Contrast Media
Imaging techniques
Evans Blue
Gadolinium DTPA
Relaxation time
Protons
Acids
Water
EB-DTPA-Gd
diethylenetriamine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

これを引用

First Functionalized MRI Contrast Agent Recognizing Vascular Lesions. / Yamamoto, Tatsuhiro; Ikuta, Kenjiro; Oi, Keiji; Abe, Kohtaro; Uwatoku, Toyokazu; Murata, Masaharu; Shigetani, Noboru; Yoshimitsu, Kengo; Shimokawa, Hiroaki; Katayama, Yoshiki.

:: analytical sciences, 巻 20, 番号 1, 01.2004, p. 5-7.

研究成果: ジャーナルへの寄稿記事

Yamamoto, T, Ikuta, K, Oi, K, Abe, K, Uwatoku, T, Murata, M, Shigetani, N, Yoshimitsu, K, Shimokawa, H & Katayama, Y 2004, 'First Functionalized MRI Contrast Agent Recognizing Vascular Lesions', analytical sciences, 巻. 20, 番号 1, pp. 5-7. https://doi.org/10.2116/analsci.20.5
Yamamoto, Tatsuhiro ; Ikuta, Kenjiro ; Oi, Keiji ; Abe, Kohtaro ; Uwatoku, Toyokazu ; Murata, Masaharu ; Shigetani, Noboru ; Yoshimitsu, Kengo ; Shimokawa, Hiroaki ; Katayama, Yoshiki. / First Functionalized MRI Contrast Agent Recognizing Vascular Lesions. :: analytical sciences. 2004 ; 巻 20, 番号 1. pp. 5-7.
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AU - Yamamoto, Tatsuhiro

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AU - Oi, Keiji

AU - Abe, Kohtaro

AU - Uwatoku, Toyokazu

AU - Murata, Masaharu

AU - Shigetani, Noboru

AU - Yoshimitsu, Kengo

AU - Shimokawa, Hiroaki

AU - Katayama, Yoshiki

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