First Functionalized MRI Contrast Agent Recognizing Vascular Lesions

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Yoshiki Katayama

研究成果: ジャーナルへの寄稿学術誌査読

7 被引用数 (Scopus)

抄録

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MR1. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.

本文言語英語
ページ(範囲)5-7
ページ数3
ジャーナルanalytical sciences
20
1
DOI
出版ステータス出版済み - 1月 2004

!!!All Science Journal Classification (ASJC) codes

  • 分析化学

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