TY - JOUR
T1 - First Functionalized MRI Contrast Agent Recognizing Vascular Lesions
AU - Yamamoto, Tatsuhiro
AU - Ikuta, Kenjiro
AU - Oi, Keiji
AU - Abe, Kohtaro
AU - Uwatoku, Toyokazu
AU - Murata, Masaharu
AU - Shigetani, Noboru
AU - Yoshimitsu, Kengo
AU - Shimokawa, Hiroaki
AU - Katayama, Yoshiki
PY - 2004/1
Y1 - 2004/1
N2 - A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MR1. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.
AB - A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MR1. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.
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U2 - 10.2116/analsci.20.5
DO - 10.2116/analsci.20.5
M3 - Article
C2 - 14753250
AN - SCOPUS:9144257232
VL - 20
SP - 5
EP - 7
JO - Analytical Sciences
JF - Analytical Sciences
SN - 0910-6340
IS - 1
ER -